Ide - insulin degrading enzyme Gene

Also Known as INSDEGM

生物種: Rattus norvegicus

遺伝子タイプ: protein coding
遺伝子ID: 25700

Summary

Enables several functions, including ATP binding activity; ATP hydrolysis activity; and peptide binding activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; amyloid-beta metabolic process; and negative regulation of proteolysis. Located in several cellular components, including cell surface; extracellular space; and peroxisomal matrix. Part of cytosolic Proteasome complex. Used to study Alzheimer's disease and type 2 diabetes mellitus. Biomarker of Alzheimer's disease and non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IDE (Insulin degrading enzyme). [provided by Alliance of Genome Resources, Apr 2022]

Ide Products (1)

mRNA Protein Name
NM_013159.2 NP_037291.1 insulin-degrading enzyme

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables ATP binding IMP
IMP: Inferred from mutant phenotype
15749695 RGD
enables ATP binding IPI
IPI: Inferred from physical interaction
17259336 RGD
enables ATP hydrolysis activity IDA
IDA: Inferred from direct assay
17259336 RGD
enables amyloid-beta binding IPI
IPI: Inferred from physical interaction
18411275 RGD
enables beta-endorphin binding IMP
IMP: Inferred from mutant phenotype
15749695 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
15494400 RGD
enables insulin binding IMP
IMP: Inferred from mutant phenotype
15749695 RGD
enables metalloendopeptidase activity IDA
IDA: Inferred from direct assay
15494400 RGD
enables metalloendopeptidase activity IMP
IMP: Inferred from mutant phenotype
15749695 RGD
enables peptide hormone binding IPI
IPI: Inferred from physical interaction
15494400 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
9000694 RGD
enables zinc ion binding IMP
IMP: Inferred from mutant phenotype
15749695 RGD
Biological Process GO Annotation Evidence 参考文献 由来
involved in amyloid-beta clearance IGI
IGI: Inferred from genetic interaction
19406747 RGD
involved in amyloid-beta clearance IMP
IMP: Inferred from mutant phenotype
10684867 RGD
involved in amyloid-beta clearance by cellular catabolic process IMP
IMP: Inferred from mutant phenotype
18941241 RGD
involved in amyloid-beta metabolic process IMP
IMP: Inferred from mutant phenotype
15749695 RGD
involved in hormone catabolic process IDA
IDA: Inferred from direct assay
15494400 RGD
involved in negative regulation of proteolysis IDA
IDA: Inferred from direct assay
9000694 RGD
involved in protein catabolic process IDA
IDA: Inferred from direct assay
11235899 RGD
involved in proteolysis involved in protein catabolic process IMP
IMP: Inferred from mutant phenotype
15749695 RGD
Cellular Component GO Annotation Evidence 参考文献 由来
located in cell surface IDA
IDA: Inferred from direct assay
10684867 RGD
part of cytosolic proteasome complex IDA
IDA: Inferred from direct assay
9000694 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
10684867 RGD
located in peroxisomal matrix IDA
IDA: Inferred from direct assay
11235899 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

insulin-degrading enzyme

  • insulin protease

  • insulinase

  • insulysin

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
製品番号 製品名 製品効果
純度 Phase
HY-101569 Darovasertib Inhibitor 99.78% Phase 3
HY-169422 GSK4418959 Inhibitor 99.07% Phase 2

Pre-clinical Phase

Bioactive Molecules (17)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-N7135 Tropolone Inhibitor 99.98% Unkown
HY-100533 IDE1 99.13% Unkown
HY-110197 6bK TFA Inhibitor 99.68% Unkown
HY-100534 IDE 2 Agonist 99.00% Unkown
HY-117878 ML345 Inhibitor 99.37% Unkown
HY-W157689 IDE-IN-2 Inhibitor 98.04% Unkown
HY-169422A GSK4418959 (enantiomer) 95.0% Unkown
HY-W038421 1,3-Bis(2,4,6-trimethylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene ≥98.0% Unkown
HY-110197A 6bK formate Inhibitor 97.02% Unkown
HY-114611 BDM44768 / Unkown
HY-12655 IDE-IN-1 Inhibitor / Unkown
HY-143401 Hit 1 Activator / Unkown
HY-182280 BDM71230 / Unkown
HY-RS06526 IDE Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W616806 Sodium 6-oxo-3,6-dihydropurin-7-ide / Unkown
HY-RS16920 Ide Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23363 Ide Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
阻害性抗体 (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-P992056 Anti-Human/Mouse LY6E Antibody (9B12) / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Ide NCBI NCBI:3416