ASAP1 - ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 Gene

Also Known as PAP; PAG2; AMAP1; DDEF1; ZG14P; CENTB4

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 50807

About ASAP1

Cytogenetic location: 8q24.21-q24.22 Genomic coordinates (GRCh38): 8:130,052,104-130,443,674 (from NCBI)

This gene has 16 transcripts (splice variants), 240 orthologues and 28 paralogues. Ubiquitous expression in bone marrow (RPKM 18.3), spleen (RPKM 15.5) and 24 other tissues.

Summary

This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and Cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

ASAP1 Products (5)

mRNA	Protein	Name
NM_001247996.2	NP_001234925.1	arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 2
NM_001362924.1	NP_001349853.1	arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 3
NM_001362925.2	NP_001349854.1	arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 4
NM_001362926.2	NP_001349855.1	arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 5
NM_018482.4	NP_060952.2	arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	12029088	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	20393563	GOA
involved in protein localization to cilium	IDA IDA: Inferred from direct assay	25673879	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in Golgi membrane	IDA IDA: Inferred from direct assay	25673879	GOA
located in trans-Golgi network membrane	IDA IDA: Inferred from direct assay	25673879	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASAP1 Protein Structure

PH

ArfGap

Ank_2

SH3_1

0
200
400
600
800
1000
1129 a.a.

Protein Preferred Names	Protein Names
arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein

ASAP1 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	ASAP1	Q9ULH1	HCK	Homo sapiens	P08631	Pull Down	12029088
Intra	ASAP1	Q9ULH1	HCK	Homo sapiens	P08631	ELISA	16636290
Intra	ASAP1	Q9ULH1	SH3KBP1	Homo sapiens	Q96B97	Anti Bait CoIP	17255943
Intra	ASAP1	Q9ULH1	SH3KBP1	Homo sapiens	Q96B97	Imaging	17255943
Intra	ASAP1	Q9ULH1	SH3KBP1	Homo sapiens	Q96B97	Pull Down	17255943
Intra	ASAP1	Q9ULH1	SH3KBP1	Homo sapiens	Q96B97	Anti Tag CoIP	15090612
Intra	ASAP1	Q9ULH1	CTTN	Homo sapiens	Q14247	X-Ray Diffraction	16636290
Intra	ASAP1	Q9ULH1	CTTN	Homo sapiens	Q14247	Pull Down	17255943
Intra	ASAP1	Q9ULH1	NCK1	Homo sapiens	P16333	ELISA	16636290
Intra	ASAP1	Q9ULH1	FYN	Homo sapiens	P06241	ELISA	16636290
Intra	ASAP1	Q9ULH1	SRC	Homo sapiens	P12931	Peptide Array	17474147
Intra	ASAP1	Q9ULH1	SRC	Homo sapiens	P12931	ELISA	16636290
Intra	ASAP1	Q9ULH1	CBLB	Homo sapiens	Q13191	Anti Bait CoIP	17255943
Intra	ASAP1	Q9ULH1	PLCG1	Homo sapiens	P19174	Fluorescence	17474147
Intra	ASAP1	Q9ULH1	PLCG1	Homo sapiens	P19174	Peptide Array	17474147
Cross	ASAP1	Q9ULH1	apc	Crosspus laevis	P70039	Pull Down	18786926

Cross: Cross-species interaction Intra: Intraspecies interaction

Diseases	Alias
Laryngeal Benign Neoplasm	Laryngeal Tumor Larynx Neoplasm Neoplasm Of Larynx Laryngeal Cancer Laryngeal Carcinoma Cancer Of Larynx
Melanoma, Uveal	Uveal Melanoma Choroidal Melanoma Melanoma Of Uvea Iris Melanoma Malignant Melanoma Of Choroid Malignant Melanoma Of Iris
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS01055	ASAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20858	Asap1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27373	Asap1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Felis catus	ASAP1	VGNC	VGNC:59952
Mus musculus	ASAP1	MGD	MGI:1342335
Rattus norvegicus	ASAP1	RGD	RGD:1307379
Macaca mulatta	ASAP1	VGNC	VGNC:69918
Canis familiaris	ASAP1	VGNC	VGNC:38153
Bos taurus	ASAP1	VGNC	VGNC:26184
Others	ASAP1	NCBI