SDHA - succinate dehydrogenase complex flavoprotein subunit A Gene

Also Known as FP; PGL5; SDH1; SDH2; SDHF; CMD1GG; MC2DN1; NDAXOA

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 6389

About SDHA

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:218,320-268,746 (from NCBI)

This gene has 19 transcripts (splice variants), 226 orthologues and is associated with 99 phenotypes. Ubiquitous expression in heart (RPKM 63.7), kidney (RPKM 34.3) and 24 other tissues.

Summary

This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

SDHA Products (3)

mRNA	Protein	Name
NM_001294332.2	NP_001281261.1	succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform 2
NM_001330758.2	NP_001317687.1	succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform 3
NM_004168.4	NP_004159.2	succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	15961414	GOA
contributes to succinate dehydrogenase (quinone) activity	IMP IMP: Inferred from mutant phenotype	7550341	GOA
enables succinate dehydrogenase (quinone) activity	IMP IMP: Inferred from mutant phenotype	24781757	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in nervous system development	IMP IMP: Inferred from mutant phenotype	16361598	GOA
involved in respiratory electron transport chain	IDA IDA: Inferred from direct assay	7550341	GOA
involved in succinate metabolic process	IDA IDA: Inferred from direct assay	7550341	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in mitochondrion	IDA IDA: Inferred from direct assay	7550341	GOA
part of respiratory chain complex II (succinate dehydrogenase)	IDA IDA: Inferred from direct assay	37098072	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SDHA Protein Structure

FAD_binding_2

Succ_DH_flav_C

0
200
400
600
664 a.a.

Protein Preferred Names	Protein Names
succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	flavoprotein subunit of complex II

SDHA Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	SDHA	P31040	SDHB	Homo sapiens	P21912	BN-PAGE	19688755
Intra	SDHA	P31040	SDHB	Homo sapiens	P21912	Anti Tag CoIP	33961781
Intra	SDHA	P31040	SDHB	Homo sapiens	P21912	Anti Tag CoIP	28514442
Intra	SDHA	P31040	CFTR	Homo sapiens	P13569	Ub Reconstruction	35156780
Intra	SDHA	P31040	SDHAF2	Homo sapiens	Q9NX18	Anti Tag CoIP	33961781
Intra	SDHA	P31040	SDHAF2	Homo sapiens	Q9NX18	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

SDHA 抗体

製品番号	製品名	アプリケーション	反応性
HY-P80318	SDHA Antibody (YA083)	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat, Zebrafish
HY-P84251	SDHA Antibody (YA3948)	WB, ICC/IF, FC, ELISA	Human, Mouse
HY-P84251A	SDHA Antibody (YA3948)(PBS only)	WB, ICC/IF, FC, ELISA	Human, Mouse
HY-P86640	SDHA Antibody (YA6332)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

関連疾患

Diseases	Alias
Cardiomyopathy, Dilated, 1gg	Dilated Cardiomyopathy 1gg CMD1GG Cardiomyopathy, Dilated 1gg Cardiomyopathy, Dilated, Type 1gg
Mitochondrial Complex Ii Deficiency, Nuclear Type 1	MC1DN2 MC2DN1 Succinate Coq Reductase Deficiency Succinate Dehydrogenase Deficiency Mitochondrial Complex I Deficiency, Nuclear Type 2 Mitochondrial Complex 1 Deficiency, Nuclear Type 2 Nuclear Type Mitochondrial Complex I Deficiency 2 Complex 2 Mitochondrial Respiratory Chain Deficiency Complex Ii Mitochondrial Respiratory Chain Deficiency Sdh-Defective Infantile Leukoencephalopathy
Neurodegeneration With Ataxia And Late-Onset Optic Atrophy	NDAXOA
Paragangliomas 5	PGL5 Paragangliomas, Type 5
Leigh Syndrome	Leigh Disease Infantile Subacute Necrotizing Encephalopathy Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency LS Sne Leigh'S Disease Leigh Syndrome Due To Mitochondrial Complex I Deficiency Necrotizing Encephalopathy, Infantile Subacute, Of Leigh Subacute Necrotizing Encephalomyelopathy Necrotizing Encephalopathy Infantile Subacute Of Leigh Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency Infantile Necrotizing Encephalomyelopathy Juvenile Subacute Necrotizing Encephalomyelopathy Leigh'S Necrotizing Encephalopathy Subacute Necrotizing Encephalopathy Juvenile Subacute Necrotizing Encephalopathy Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency Leigh Syndrome Due To Mitochondrial Complex V Deficiency Encephalopathy, Subacute Necrotizing, Infantile Encephalopathy, Subacute Necrotizing, Juvenile Maternally Inherited Leigh Syndrome Subacute Necrotising Encephalomyelopathy Subacute Necrotising Encephalopathy
Mitochondrial Complex Ii Deficiency	Isolated Mitochondrial Respiratory Chain Complex Ii Deficiency Isolated Succinate-Coenzyme Q Reductase Deficiency Isolated Succinate-Coq Reductase Deficiency Isolated Succinate-Ubiquinone Reductase Deficiency Mitochondrial Respiratory Chain Complex Ii Deficiency Complex 2 Mitochondrial Respiratory Chain Deficiency Succinate Coq Reductase Deficiency Succinate Dehydrogenase Deficiency Isolated Succinate Dehydrogenase Deficiency Succinate-Coenzyme Q Reductase Deficiency
Polymyoclonus, Infantile	Infantile Polymyoclonus
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma
Otitis Media	Opsoclonus-Myoclonus Syndrome OMS Otitis Media, Susceptibility To Kinsbourne Syndrome Otitis Media, Chronic/Recurrent Come/Rom Ataxo-Opso-Myoclonus Syndrome Dancing Eye Syndrome Dancing Eye-Dancing Feet Syndrome Oma Syndrome Opsoclonus Myoclonus Syndrome Opsoclonus-Myoclonus-Ataxia Syndrome Poma Syndrome Paraneoplastic Opsoclonus-Myoclonus Paraneoplastic Opsoclonus-Myoclonus-Ataxia Syndrome Opsoclonus Myoclonus OM {Otitis Media, Susceptibility To} Infectious Otitis Media
Paraganglioma	Chemodectoma Glomus Body Tumor Paragangliomas Carotid Body Paraganglioma Extra-Adrenal Paraganglioma
Pilocytic Astrocytoma	Juvenile Pilocytic Astrocytoma Grade I Astrocytic Tumor Piloid Astrocytoma
Paragangliomas 1	Carotid Body Tumor Paragangliomata Pgl Chemodectomas Carotid Body Tumors Glomus Jugulare Tumors Carotid Body Paraganglioma PGL1 Cbt1 Glomus Tumor Glomus Tumors Familial 1 Paragangliomas Familial 1 Glomus Jugulare Tumor Paragangliomas, Familial, 1 Glomus Tumors, Familial, 1 Paraganglioma, Carotid Body Paragangliomas, Familial Nonchromaffin, 1 Paragangliomas 1, With Or Without Deafness Cbt Paraganglioma - Glomus Jugulare Pgl 1 Sdhd-Related Hereditary Paraganglioma-Pheochromocytoma Syndrome Chemodectoma Familial Non-Chromaffin Paragangliomas 1 Familial Paragangliomas Non-Chromaffin 1 With Or Without Deafness Paraganglioma Carotid Body Paragangliomas, Type 1 Paraganglioma Extra-Adrenal Paraganglioma Glomus Tympanicum Tumor
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Rhabdomyosarcoma
Hereditary Paraganglioma-Pheochromocytoma Syndromes	Hereditary Pheochromocytoma-Paraganglioma Hereditary Paraganglioma-Pheochromocytoma Familial Pheochromocytoma-Paraganglioma Paragangliomas 2 Paragangliomas 3 Paragangliomas 4 Sdhx-Related Paraganglioma-Pheochromocytoma Familial Paraganglioma Syndrome Familial Paraganglioma-Pheochromocytoma Syndromes Fpgl Fpgl/Pheo Paragangliomas 1 Paraganglioma
Leigh Syndrome With Leukodystrophy	Infantile Subacute Necrotizing Encephalopathy With Leukodystrophy Leigh Disease With Leukodystrophy
Bap1 Tumor Predisposition Syndrome	Bap1-Related Tumor Predisposition Syndrome Common Syndrome Bap1 Cancer Syndrome Bap1-Tpds Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, And Other Internal Neoplasms Tumor Predisposition Syndrome Tumor Susceptibility Linked To Germline Bap1 Mutations Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, Other Internal Neoplasms Tumor Predisposition
Inherited Cancer-Predisposing Syndrome	Hereditary Cancer-Predisposing Syndrome
Familial Isolated Dilated Cardiomyopathy	Familial Or Idiopathic Dilated Cardiomyopathy
Carney Triad	Gastric Leiomyosarcoma, Pulmonary Chondroma, And Extraadrenal Paraganglioma
Graves Ophthalmopathy	Graves Orbitopathy Thyroid Associated Ophthalmopathy Thyroid Eye Disease Thyroid-Associated Ophthalmopathy
Neural Crest Tumor	Neural Crest-Derived Tumors
Hyperthyroidism	Overactive Thyroid
Barth Syndrome	3-Methylglutaconic Aciduria Type 2 BTHS Cardioskeletal Myopathy With Neutropenia And Abnormal Mitochondria Mga Type Ii Mga2 Mgca2 Mga Type 2 3-Methylglutaconic Aciduria Type Ii 3-Methylglutaconic Aciduria, Type Ii Mga, Type Ii 3-Methylglutaconicaciduria Type 2 3-Methylglutaconicaciduria Type Ii Taz Defect 3 Methylglutaconic Aciduria, Type Ii Dnajc19 Defect Cardioskeletal Myopathy-Neutropenia Syndrome X-Linked Cardioskeletal Myopathy And Neutropenia 3-Alpha-Methylglutaconic Aciduria Type 2 Agm2 Cardioskeletal Myopathy-Neutropenia Invm Left Ventricular Non-Compaction Isolated X-Linked Non-Compaction Of Left Ventricular Myocardium Isolated X-Linked Agammaglobulinemia 2, Autosomal Recessive
Kearns-Sayre Syndrome	Ophthalmoplegia Mitochondrial Cytopathy KSS Ophthalmoplegia, Pigmentary Degeneration Of Retina, And Cardiomyopathy Oculocraniosomatic Syndrome Chronic Progressive External Ophthalmoplegia With Myopathy Cpeo With Myopathy Total Ophthalmoplegia Ophthalmoplegia-Plus Syndrome Ophthalmoplegia, Progressive External, With Ragged-Red Fibers Cpeo With Ragged-Red Fibers Oculomotor Paralysis Renal Tubulopathy, Diabetes Mellitus, And Cerebellar Ataxia Due To Duplication O Renal Tubulopathy, Diabetes Mellitus, And Cerebellar Ataxia Due To Duplication Of Mitochondrial Dna Proximal Tubulopathy, Diabetes Mellitus And Cerebellar Ataxia Cpeo With Ragged Red Fibers Ophthalmoplegia Plus Syndrome Ophthalmoplegia, Progressive External, With Ragged Red Fibers Kearns-Sayre Mitochondrial Cytopathy Mitochondrial Myopathies
Persistent Generalized Lymphadenopathy	Pgl Persistant Generalized Lymphadenopathy
Paraganglioma And Gastric Stromal Sarcoma	Carney-Stratakis Syndrome Paraganglioma And Gastrointestinal Stromal Tumor Carney Dyad Carney-Stratakis Dyad Of Paraganglioma And Gastric Stromal Sarcoma Paraganglioma And Gist Carney-Stratakis Dyad Gist-Paraganglioma Dyad PGGSS Paraganglioma, Gastric Stromal Sarcoma Gastrointestinal Stromal Tumors
Leukodystrophy	Leukodystrophies
Extra-Adrenal Pheochromocytoma	Pheochromocytoma, Extra-Adrenal
Chondroma	Central Chondroma Enchondroma
Gastric Leiomyosarcoma	Leiomyosarcoma Of Stomach
Lymph Node Disease	Abnormality Of The Lymph Nodes Disorder Of Lymph Node
Fumarase Deficiency	Fumaric Aciduria FMRD Fumarate Hydratase Deficiency Deficiency, Fumarase
Hashimoto Thyroiditis	Autoimmune Thyroiditis Hashimoto Struma Hashimoto'S Thyroiditis Chronic Lymphocytic Thyroiditis Lymphocytic Thyroiditis Hashimoto Disease Ht Hashimoto'S Disease Hashimoto'S Syndrome Hypothyroidism, Autoimmune Autoimmune Chronic Lymphocytic Thyroiditis Chronic Lymphocytic Thyroiditides Hashimoto Syndrome Hashimotos Thyroiditis Hashimoto Thyroiditis, Susceptibility To Thyroiditis, Autoimmune Lymphomatous Thyroiditis Lymphoid Thyroiditis Chronic Lymphadenoid Thyroiditis Autoimmune Lymphocytic Chronic Thyroiditis Goitre Lymphomatosa Hashitoxicosis Hashimoto Hypothyroidism Lymphadenoid Goitre Struma Lymphomatosa Hyperthyroidism With Hashimoto Disease Hashimoto Thyrotoxicosis Thyrotoxicosis Due To Hashimoto Thyroiditis Struma Lymphomatosis Lymphadenoid Struma
Leiomyoma Cutis	Cutaneous Leiomyoma Leiomyoma Of The Skin
Dermis Tumor	Dermis Tumour Neoplasm Of Dermis Tumor Of Dermis Tumour Of Dermis
Foster-Kennedy Syndrome	Disorder Of The Optic Nerve Optic Nerve Diseases Disease Of Optic Cranial Nerve Disease Of Optic Nerve Disease Of Second Cranial Nerve Disorder Of Optic Cranial Nerve Disorder Of Second Cranial Nerve Disorders Of 2nd Nerve
Spastic Quadriplegia	Spastic Quadriplegic Cerebral Palsy Quadriplegic Infantile Cerebral Palsy Tetraplegic Infantile Cerebral Palsy Cerebral Palsy Spastic Quadriplegic Quadriplegic Cerebral Palsy Spastic Quadriplegia Cerebral Palsy Spastic Tetraplegia Cerebral Palsy Cerebral Palsy, Quadriplegic, Infantile Cerebral Palsy With Spastic Tetraplegia Congenital Spastic Quadriplegia Spastic Tetraplegic Cerebral Palsy Congenital Quadriplegia Nos Tetraplegic Cerebral Palsy
Scrotum Melanoma	Melanoma Of Scrotum
Malignant Pheochromocytoma	Pheochromocytoma, Malignant
Adrenal Medulla Cancer	Adrenal Medulla Neoplasm Adrenal Medulla Tumor Malignant Neoplasm Of Adrenal Medulla Malignant Tumor Of The Adrenal Medulla Adrenal Medulla Carcinoma Neoplasm Of Adrenal Medulla
Endocrine Organ Benign Neoplasm
Multiple Endocrine Neoplasia, Type Iia	Multiple Endocrine Neoplasia Type 2a Sipple Syndrome Multiple Endocrine Neoplasia Type 2 MEN2A Men2 Ptc Syndrome Multiple Endocrine Neoplasia, Type 2 Multiple Endocrine Neoplasia Iia Men 2a Pheochromocytoma And Amyloid Producing Medullary Thyroid Carcinoma Multiple Endocrine Neoplasia, Type 2a Pheochromocytoma And Amyloid-Producing Medullary Thyroid Carcinoma Multiple Endocrine Neoplasia Ii Men2 Syndrome Men-2a Syndrome Multiple Neoplasia 2a Multiple Neoplasia Type 2
Myopathy	Muscular Diseases Myopathies
Quadriplegia	Tetraplegia Tetraplegias
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Cataract 38	CTRCT38 Catc5 Autosomal Recessive Congenital Cataract 5 Cataract, Autosomal Recessive Congenital 5 Cataract 38, Autosomal Recessive Cataract, Type 38
Mitochondrial Metabolism Disease	Abnormality Of Mitochondrial Metabolism Mitochondrial Diseases
Infantile Cerebellar-Retinal Degeneration	ICRD Infantile Cerebellar Retinal Degeneration Degeneration, Cerebellar-Retinal, Infantile
Cardiomyopathy, Dilated, 1c, With Or Without Left Ventricular Noncompaction	Left Ventricular Noncompaction 3 Dilated Cardiomyopathy 1c CMD1C Cardiomyopathy, Hypertrophic, 24 Dilated Cardiomyopathy With Left Ventricular Noncompaction Cardiomyopathy, Dilated, 1c, With Or Without Lvnc Cmdc1 Dilated Cardiomyopathy 1c With Or Without Left Ventricular Noncompaction Cardiomyopathy, Dilated 1c, With Or Without Left Ventricular Non-Compaction Cardiomyopathy Dilated With Left Ventricular Noncompaction Cardiomyopathy, Familial Hypertrophic 24 CMH24 Left Ventricular Non-Compaction 3 LVNC3 Cardiomyopathy, Dilated 1c Familial Hypertrophic Cardiomyopathy 24 Cardiomyopathy, Dilated, 1c
3-Methylglutaconic Aciduria, Type Iii	Optic Atrophy 3-Methylglutaconic Aciduria Type 3 Costeff Syndrome Mga3 Costeff Optic Atrophy Syndrome Optic Atrophy Plus Syndrome Infantile Optic Atrophy With Chorea And Spastic Paraplegia 3-Methylglutaconic Aciduria Type Iii Autosomal Recessive Optic Atrophy Plus Syndrome Autosomal Recessive Optic Atrophy Type 3 Opa3 Defect MGCA3 Mga, Type Iii Iraqi Jewish Optic Atrophy Plus Mga Type Iii Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia Iraqi-Jewish 'Optic Atrophy Plus' Optic Atrophy 3, Autosomal Recessive Opa3, Autosomal Recessive Opa3-Related 3-Methylglutaconic Aciduria Iraqi-Jewish Optic Atrophy Plus Atrophy Of Optic Disc 3-Alpha Methylglutaconic Aciduria Type Iii Optic Atrophy 3 Optic Atrophy Infantile With Chorea And Spastic Paraplegia Autosomal Recessive Opa3 Autosomal Recessive Optic Atrophy 3 3-Methylglutaconic Aciduria 3 3-Alpha-Methylglutaconic Aciduria Type 3 Optic Atrophy 3 Autosomal Recessive Atrophy, Optic Atrophy, Optic, Plus Syndrome Optic Nerve Atrophy Primary Optic Atrophy Oa - [Optic Atrophy] Second Cranial Nerve Atrophy Second Cranium Nerve Atrophy
Complex Partial Epilepsy	Epilepsy, Complex Partial Complex Partial Epileptic Seizure Epilepsy, Psychomotor Psychomotor Epilepsy
Von Hippel-Lindau Syndrome	Von Hippel-Lindau Disease Vhl Vhl Syndrome VHLS Von Hippel-Lindau Syndrome, Modifier Of Hippel Lindau Syndrome Angiomatosis Retinae Cerebelloretinal Angiomatosis, Familial Hippel-Lindau Disease Familial Cerebelloretinal Angiomatosis Lindau Disease VHLD
Spastic Paraplegia 38, Autosomal Dominant	SPG38 Hereditary Spastic Paraplegia 38 Autosomal Dominant Spastic Paraplegia Type 38 Autosomal Dominant Spastic Paraplegia 38
Myopathy, Lactic Acidosis, And Sideroblastic Anemia 3	MLASA3
Gastric Liposarcoma	Liposarcoma Of The Stomach
Cerebral Angioma	Hemangioma Of Cerebrum Cerebral Hemangioma
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Neurofibromatosis, Type I	Von Recklinghausen Disease Neurofibromatosis 1 Neurofibromatosis, Type 1 NF1 Neurofibromatosis, Peripheral Type Neurofibromatosis Type I Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion Familial Spinal Neurofibromatosis Fsnf Peripheral Neurofibromatosis Von Recklinghausen'S Neurofibromatosis Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion Neurofibromatosis Peripheral Type Von Recklinghausen Syndrome Neurofibromatosis Type 1 Von Recklinghausen Neuropathy Nf1 - [Neurofibromatosis Type 1] Recklinghausen Disease
Mitochondrial Myopathy	Mitochondrial Myopathies Mitochondrial Cytopathy Myopathies In Mitochondrial Disorders
Mitochondrial Complex I Deficiency, Nuclear Type 1	Mitochondrial Complex I Deficiency Nadh:Q(1) Oxidoreductase Deficiency MC1DN1 Nadh-Coenzyme Q Reductase Deficiency Isolated Mitochondrial Respiratory Chain Complex I Deficiency Isolated Nadh-Coenzyme Q Reductase Deficiency Isolated Nadh-Coq Reductase Deficiency Isolated Nadh-Ubiquinone Reductase Deficiency Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of Nuclear Type Mitochondrial Complex I Deficiency 1 Isolated Complex I Deficiency Complex 1 Mitochondrial Respiratory Chain Deficiency Nadh Coenzyme Q Reductase Deficiency Complex I Mitochondrial Respiratory Chain Deficiency Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I Nadh:Ubiquinone Oxidoreductase Deficiency Complex I, Mitochondrial Respiratory Chain, Deficiency Of
Cowden Syndrome	Cowden Disease Multiple Hamartoma Syndrome Cowden'S Disease Lhermitte-Duclos Disease Cd Cs Mham Dysplastic Gangliocytoma Of Cerebellum Cowden'S Syndrome Hamartoma Syndrome, Multiple
Leber Hereditary Optic Neuropathy, Modifier Of	Leber Optic Atrophy Leber Hereditary Optic Neuropathy LHON Leber'S Hereditary Optic Neuropathy Leber Optic Atrophy, Susceptibility To Leber'S Optic Atrophy LOAM Loas Leber'S Disease Leber'S Optic Neuropathy Optic Atrophy, Hereditary, Leber Lhon, Modifier Of Optic Atrophy, Leber Type Hereditary Optic Neuroretinopathy Leber Hereditary Optic Atrophy Loa Optic Atrophy Leber Type Leber Hereditary Optic Neuropathy, Modifier Leber Hereditary Optic Neuropathy Susceptibility Modifier Of Leber Hereditary Optic Neuropathy Lebers Hereditary Optic Neuropathy Leber Congenital Amaurosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS12590	SDHA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-131453	Mitochondrial respiration-IN-1	Inhibitor	/	Unkown
HY-180786	DdBIC		/	Unkown
HY-RS18790	Sdha Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25279	Sdha Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	SDHA	RGD	RGD:621557
Canis familiaris	SDHA	VGNC	VGNC:45949
Macaca mulatta	SDHA	VGNC	VGNC:84490
Bos taurus	SDHA	VGNC	VGNC:34388
Felis catus	SDHA	VGNC	VGNC:102313
Mus musculus	SDHA	MGD	MGI:1914195
Others	SDHA	NCBI