TUB - TUB bipartite transcription factor Gene

Also Known as rd5; RDOB

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 7275

About TUB

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:8,019,059-8,106,243 (from NCBI)

This gene has 3 transcripts (splice variants), 208 orthologues, 5 paralogues and is associated with 3 phenotypes. Broad expression in brain (RPKM 18.8), endometrium (RPKM 10.0) and 21 other tissues.

Summary

This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

TUB Products (2)

mRNA	Protein	Name
NM_003320.5	NP_003311.2	tubby protein homolog isoform a
NM_177972.3	NP_813977.1	tubby protein homolog isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables G protein-coupled receptor binding	IDA IDA: Inferred from direct assay	28154160	GOA
enables intraciliary transport particle A binding	IDA IDA: Inferred from direct assay	28154160	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	20889716	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
acts upstream of or within intraciliary transport	IDA IDA: Inferred from direct assay	28154160	GOA
involved in positive regulation of phagocytosis	IDA IDA: Inferred from direct assay	19837063	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in cilium	IDA IDA: Inferred from direct assay	28154160	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	28154160	GOA
located in nucleus	IDA IDA: Inferred from direct assay	28154160	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TUB Protein Structure

Tub

0
100
200
300
400
506 a.a.

Protein Preferred Names	Protein Names
tubby protein homolog	tubby bipartite transcription factor

Recombinant TUB Proteins

製品番号	製品名	アクセッション番号	純度
HY-P701073	Tubby Protein, Human (His)	P50607-1 (M1-E506)	≥ 95%, as determined by reducing SDS-PAGE.

TUB 抗体

製品番号	製品名	アプリケーション	反応性
HY-P87122	TUB Antibody (YA6815)	WB, IHC-P, FC	Human, Mouse, Rat

関連疾患

Diseases	Alias
Retinal Dystrophy And Obesity	RDOB Dystrophy, Retinal, And Obesity
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Coffin-Siris Syndrome 2	CSS2 Mrd14 Mental Retardation, Autosomal Dominant 14 Autosomal Dominant Mental Retardation 14 Coffin-Siris Syndrome, Type 2
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Cone Dystrophy	Retinal Cone Dystrophy Dystrophy, Cone Cone Dystrophy 3
Multidrug-Resistant Tuberculosis	Tuberculosis, Multidrug-Resistant Tuberculosis Multidrug-Resistant
Bagassosis	Sugar Cane Worker Pneumonitis Bagasse Workers' Lung Bagasse Disease Bagasse Disease Or Pneumonitis Bagasse Workers' Disease Fibrosis Of Lung With Bagassosis Sugar Cane Workers' Hypersensitivity Pneumonitis Bagasse Pneumonitis Hypersensitivity Pneumonitis With Bagassosis
Tinea Nigra	Microsporosis Nigra Infection By Cladosporium Werneckii Keratomycosis Nigricans Tinea Palmaris Nigra Keratomycosis Nigricans Palmaris
Night Blindness	Nyctalopia
Cardiomyopathy, Familial Hypertrophic, 16	Hypertrophic Cardiomyopathy 16 CMH16 Cardiomyopathy, Hypertrophic, 16 Cardiomyopathy Familial Hypertrophic 16 Cardiomyopathy, Familial Hypertrophic 16 Cardiomyopathy, Hypertrophic, Familial, Type 16
Phaeohyphomycosis	Infection By Dematiacious Fungi Phaehyphomycosis Phaeomycosis Pheohyphomycosis Infection By Dematiacious Fungi [Phaehyphomycosis] Dematiaceous Fungal Infection
Cardiomyopathy, Familial Hypertrophic, 18	Hypertrophic Cardiomyopathy 18 CMH18 Cardiomyopathy, Hypertrophic, 18 Cardiomyopathy Familial Hypertrophic 18 Cardiomyopathy, Familial Hypertrophic 18 Cardiomyopathy, Hypertrophic, Familial, Type 18
Lip Cancer	Malignant Neoplasm Of Lip Malignant Neoplasm Of Oral Aspect Of Lip, Not Specified Whether Upper Or Lower Malignant Tumour Of Lip Lip Neoplasms Malignant Neoplasm Of Commissure Of Lip Malignant Neoplasm Of External Lip, Not Specified As Upper Or Lower Malignant Neoplasm Of Labial Commissure Of Lip Malignant Neoplasm Of Lip, External Malignant Neoplasm Of Lip, Inner Aspect Malignant Neoplasm Of Lip, Vermilion Border Malignant Neoplasm Of Lower Lip, Buccal Aspect Malignant Neoplasm Of Lower Lip, Inner Aspect Malignant Neoplasm Of Lower Lip, Mucosa Malignant Neoplasm Of Lower Lip, Oral Aspect Malignant Neoplasm Of Other Sites Of Lip Malignant Neoplasm Of Vermilion Border Of Lip Malignant Tumor Of Commissure Of Lip Malignant Tumor Of Labial Mucosa Malignant Tumor Of Lip Malignant Tumor Of Lower Labial Mucosa Malignant Tumor Of The Lip Malignant Tumour Of Labial Commissure Cancer Of Lip Primary Malignant Neoplasm Of Vermilion Border Of Upper Lip Upper Lip Cancer Lower Lip Cancer Primary Malignant Neoplasm Of Vermilion Border Of Lower Lip Primary Malignant Neoplasm Of Vermilion Border Of Lip Malignant Neoplasm Of Lipstick Area Of Upper Lip Malignant Neoplasm Of Upper Lip Nos Malignant Neoplasm Of Vermilion Border Of Upper Lip Malignant Neoplasm Of Lipstick Area Of Lower Lip Malignant Neoplasm Of Lower Lip Nos Malignant Neoplasm Of Vermilion Border Of Lower Lip Malignant Neoplasm Of Vermilion Border Nos Malignant Neoplasm Of Buccal Aspect Of Upper Lip Malignant Neoplasm Of Frenulum Of Upper Lip Malignant Neoplasm Of Mucosa Of Upper Lip Malignant Neoplasm Of Oral Aspect Of Upper Lip Malignant Neoplasm Of Buccal Aspect Of Lower Lip Malignant Neoplasm Of Frenulum Of Lower Lip Malignant Neoplasm Of Mucosa Of Lower Lip Malignant Neoplasm Of Oral Aspect Of Lower Lip Malignant Neoplasm Of Buccal Aspect Of Lip, Not Specified Whether Upper Or Lower Malignant Neoplasm Of Frenulum Of Lip, Not Specified Whether Upper Or Lower Malignant Neoplasm Of Mucosa Of Lip, Not Specified Whether Upper Or Lower Primary Malignant Neoplasm Of Commissure Of Lip Primary Malignant Neoplasm Of Lip Malignant Neoplasm Of Lip, Unspecified
Bird Fancier'S Lung	Bird Fancier Lung Pigeon Breeder'S Lung Avian Hypersensitivity Pneumonitis Bird Breeder'S Lung Bird-Fancier'S Lung Bird-Fanciers' Lung Poultry Worker'S Lung Pigeon-Breeder Lung Disease Pigeon Breeders Lung Avian Protein Hypersensitivity Bird Breeders' Disease Bird Breeders' Lung Bird Fanciers' Lung Bird Fanciers' Disease Bfl - [Bird Fancier Lung] Fanciers' Disease Fanciers' Lung
Cardiomyopathy, Familial Hypertrophic, 17	Hypertrophic Cardiomyopathy 17 CMH17 Cardiomyopathy, Hypertrophic, 17 Cardiomyopathy Familial Hypertrophic 17 Cardiomyopathy, Familial Hypertrophic 17 Cardiomyopathy, Hypertrophic, Familial, Type 17
Cerebral Amyloid Angiopathy, Itm2b-Related, 1	Dementia, Familial British Fbd Presenile Dementia With Spastic Ataxia Familial British Dementia Abri Amyloidosis Cerebral Amyloid Angiopathy, British Type Itm2b-Related Cerebral Amyloid Angiopathy 1 Familial Dementia, British Type Cerebral Amyloid Angiopathy, Itm2b-Related 1 CAA-ITM2B1 Cerebral Amyloid Angiopathy British Type Dementia, Familial, British

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (16)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-13250	Silvestrol aglycone		99.95%	Unkown
HY-148452	eIF4A3-IN-18	Inhibitor	99.58%	Unkown
HY-148446	eIF4A3-IN-12	Inhibitor	99.70%	Unkown
HY-148443	eIF4A3-IN-9	Inhibitor	99.71%	Unkown
HY-148445	eIF4A3-IN-11	Inhibitor	99.24%	Unkown
HY-148448	eIF4A3-IN-14	Inhibitor	99.81%	Unkown
HY-148449	eIF4A3-IN-15	Inhibitor	/	Unkown
HY-148450	eIF4A3-IN-16	Inhibitor	99.96%	Unkown
HY-148451	eIF4A3-IN-17	Inhibitor	99.56%	Unkown
HY-RS15244	TUB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-175881	3-Formyl-L-tyrosine-oxime-Val-Cit-PAPB		/	Unkown
HY-175884	TUB-010 drug-linker		/	Unkown
HY-177413	Tub114	Inhibitor	/	Unkown
HY-168326	Antiproliferative agent-64	Inhibitor	/	Unkown
HY-RS17577	Tub Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24037	Tub Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Macaca mulatta	TUB	VGNC	VGNC:78672
Bos taurus	TUB	VGNC	VGNC:36503
Mus musculus	TUB	MGD	MGI:2651573
Rattus norvegicus	TUB	RGD	RGD:3918
Felis catus	TUB	VGNC	VGNC:66696
Canis familiaris	TUB	VGNC	VGNC:47986
Others	TUB	NCBI