MANF - mesencephalic astrocyte derived neurotrophic factor Gene

Also Known as ARP; ARMET

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 7873

About MANF

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:51,385,291-51,389,397 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 71.3), appendix (RPKM 44.4) and 25 other tissues.

Summary

The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014]

MANF Products (1)

mRNA	Protein	Name
NM_006010.6	NP_006001.5	mesencephalic astrocyte-derived neurotrophic factor precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	25543119	GOA
enables sulfatide binding	IPI IPI: Inferred from physical interaction	29497057	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in regulation of response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	29497057	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in endoplasmic reticulum lumen	IDA IDA: Inferred from direct assay	29497057	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MANF Protein Structure

Armet

0
100
182 a.a.

Protein Preferred Names	Protein Names
mesencephalic astrocyte-derived neurotrophic factor	arginine-rich, mutated in early stage tumors

MANF Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	MANF	P55145	RTN1	Homo sapiens	Q16799-3	Pull Down	25543119
Intra	MANF	P55145	RTN1	Homo sapiens	Q16799-3	Y2H	25543119
Intra	MANF	P55145	RTN1	Homo sapiens	Q16799-3	Anti Tag CoIP	25543119
Intra	MANF	P55145	BCL2L15	Homo sapiens	Q5TBC7	Anti Tag CoIP	33961781
Intra	MANF	P55145	BCL2L15	Homo sapiens	Q5TBC7	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MANF Proteins

製品番号	製品名	アクセッション番号	純度
HY-P7605	ARMET/MANF Protein, Human (HEK293, His)	P55145 (L25-L182)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P76731	ARMET/MANF Protein, Human (HEK293, Fc)	A8K878 (L28-L185)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P71940A	ARMET/MANF Protein, Human (His)	P55145 (L25-L182)	≥ 95%, as determined by reducing SDS-PAGE.

MANF 抗体

製品番号	製品名	アプリケーション	反応性
HY-P811306	ARMET Antibody	WB, IHC-P	Human, Mouse, Rat

関連疾患

Diseases	Alias
Multiple Epiphyseal Dysplasia	Med Polyepiphyseal Dysplasia Edm Epiphyseal Dysplasia, Multiple, 1 Epiphyseal Dysplasia, Multiple, 2 Epiphyseal Dysplasia, Multiple, 3 Epiphyseal Dysplasia, Multiple, 4 Epiphyseal Dysplasia, Multiple, 5 Epiphyseal Dysplasia, Multiple Edm1 Edm2 Edm3 Edm4 Edm5 Epiphyseal Dysplasia, Fairbank Type Epiphyseal Dysplasia, Ribbing Type Multiple Epiphyseal Dysplasia, Autosomal Dominant Multiple Epiphyseal Dysplasia, Autosomal Recessive Rmed Dysplasia, Epiphyseal, Multiple Osteochondrodysplasias
Wolfram Syndrome 2	WFS2
Wolfram Syndrome	Didmoad Syndrome Didmoad Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Wfs Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness Didmoadud Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS08017	MANF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18040	Manf Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24514	Manf Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Bos taurus	MANF	VGNC	VGNC:31171
Felis catus	MANF	VGNC	VGNC:80621
Canis familiaris	MANF	VGNC	VGNC:42951
Mus musculus	MANF	MGD	MGI:1922090
Rattus norvegicus	MANF	RGD	RGD:1307252
Macaca mulatta	MANF	VGNC	VGNC:110354
Others	MANF	NCBI