ODAD4 - outer dynein arm docking complex subunit 4 Gene
Also Known as TTC25
生物種: Homo sapiens (human)
Summary
This gene encodes a tetratricopeptide repeat domain-containing protein that localizes to ciliary axonmenes and plays a role in the docking of the outer dynein arm to cilia. Mutations in this gene cause severely reduced ciliary motility and the disorder CILD35 (ciliary dyskinesia,primary, 35). Primary ciliary dyskinesia is often associated with recurrent respiratory infections, immotile spermatozoa, and situs inversus; an inversion in left-right body symmetry. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017]
ODAD4 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_001350319.2 | NP_001337248.1 | outer dynein arm-docking complex subunit 4 isoform 2 |
| Molecular Function GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
25416956 | GOA |
| Biological Process GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| involved in cilium movement |
IDA
IDA: Inferred from direct assay
|
27486780 | GOA |
| involved in epithelial cilium movement involved in determination of left/right asymmetry |
IMP
IMP: Inferred from mutant phenotype
|
27486780 | GOA |
| involved in mucociliary clearance |
IMP
IMP: Inferred from mutant phenotype
|
27486780 | GOA |
| involved in outer dynein arm assembly |
IDA
IDA: Inferred from direct assay
|
27486780 | GOA |
| involved in protein localization to motile cilium |
IMP
IMP: Inferred from mutant phenotype
|
27486780 | GOA |
| Cellular Component GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| located in 9+2 motile cilium |
IDA
IDA: Inferred from direct assay
|
27486780 | GOA |
| located in axoneme |
IDA
IDA: Inferred from direct assay
|
27486780 | GOA |
| part of outer dynein arm docking complex |
IDA
IDA: Inferred from direct assay
|
27486780 | GOA |
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| Protein Preferred Names | Protein Names | |
|---|---|---|
|
outer dynein arm-docking complex subunit 4 |
|
|
ODAD4 Protein-protein interaction Information
|
Type
|
タンパク質名 | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | 参考文献 |
|---|---|---|---|---|---|---|---|
|
Intra
|
ODAD4 | Q96NG3 | KRT40 | Homo sapiens | Q6A162 | 25416956 | |
|
Intra
|
ODAD4 | Q96NG3 | NECAB2 | Homo sapiens | Q7Z6G3-2 | 25416956 | |
|
Intra
|
ODAD4 | Q96NG3 | MKRN3 | Homo sapiens | Q13064 | 25416956 | |
|
Intra
|
ODAD4 | Q96NG3 | MYOG | Homo sapiens | P15173 | 25416956 | |
|
Intra
|
ODAD4 | Q96NG3 | MYOG | Homo sapiens | P15173 | 25416956 | |
|
Intra
|
ODAD4 | Q96NG3 | GOLGA2 | Homo sapiens | Q08379 | 25416956 | |
|
Intra
|
ODAD4 | Q96NG3 | GOLGA2 | Homo sapiens | Q08379 | 25416956 | |
|
Intra
|
ODAD4 | Q96NG3 | CEP70 | Homo sapiens | Q8NHQ1 | 25416956 | |
|
Intra
|
ODAD4 | Q96NG3 | CCDC85B | Homo sapiens | Q15834 | 25416956 | |
|
Intra
|
ODAD4 | Q96NG3 | MEOX2 | Homo sapiens | P50222 | 25416956 | |
|
Intra
|
ODAD4 | Q96NG3 | MEOX2 | Homo sapiens | P50222 | 25416956 |