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製品番号: HY-N19830

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Guavenoic acid

Guavenoic acid is a triterpenoid compound that can be isolated from fresh leaves of Psidium guajava. Guavenoic acid protects cells in cellular oxidative damage models, inhibits intracellular ROS production, and suppresses cell apoptosis. Guavenoic acid significantly enhances cellular proliferation, promotes insulin synthesis and secretion, and upregulates the messenger RNA expression of insulin gene, PDX-1 and MafA. Guavenoic acid can be used in the research of diseases such as pancreatic islet β-cell tumors.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 585527-12-4
分子式: C₃₀H₄₆O₆
分子量:502.68

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Guavenoic acid 構造式

CAS 番号: 585527-12-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Guavenoic acid (0.3-30 nM, 48 h) protects cells, inhibits intracellular ROS production, and suppresses cell apoptosis in the H₂O₂-induced oxidative damage model of INS-1 cells^[2].
Guavenoic acid (0.3-30 nM, 48 h) promotes the proliferation of INS-1 cells, enhances cellular insulin synthesis capacity, strengthens both basal insulin secretion and glucose-stimulated insulin secretion functions, and upregulates the mRNA expression levels of insulin gene, PDX-1, and MafA in INS-1 cells under a glucose-stimulated insulin secretion model with glucose concentrations of 5.6 and 16.7 mM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[2]

Cell Line:

650 μM H₂O₂ challenges the INS-1 cells
Concentration:

0.3, 1, 3, 10, 30 nM
Incubation Time:

48 h
Result:

Suppresses cell apoptosis.

化学情報

CAS 番号 585527-12-4
分子量 502.68
分子式 C₃₀H₄₆O₆
SMILES

C[C@@]12[C@]3([H])[C@]([C@]4(C([C@@]5([H])[C@@](CC4)(CCC([C@@H]5C)=C)C(O)=O)=CC3)C)(C[C@H]([C@@]1([H])[C@@](C)([C@H]([C@@H](C2)O)O)CO)O)C
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Begum S, et al. Two new triterpenoids from the fresh leaves of Psidium guajava. Planta Med. 2002;68(12):1149-1152. [Content Brief]

[2]. Jing-Ru WANG, et al. Effects of guavenoic acid on protection against oxidative damage in INS-1 Cells and its mechanisms. Chinese Pharmaceutical Journal ; (24): 233-238, 2015.

[3]. Kaihe YE, et al. Promoting effects of Guavenoic acid (GA)on proliferation,insulin synthesis and secretion in INS-1 cells and their mechanism. Chinese Pharmacological Bulletin ; (12): 1681-1687, 2014.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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