Ilicicolin H
Based on 1 Customer Validation
Ilicicolin H is a selective and non-ATP-competitive phosphoglycerate kinase 1 (PGK1) (IC50 = 9.02 μM) and mitochondrial cytochrome bc1 reductase (IC50 = 2-3 ng/mL) inhibitor. Ilicicolin H directly binds to PGK1 with KD of 60 μM .Ilicicolin H can inhibit cell proliferation and induce apoptosis. Ilicicolin H can inhibit the lactate production and glucose uptake of hepatocellular carcinoma (HCC) cells. Ilicicolin H has a broad antifungal spectrum including C. albicans, Cryptococcus and A. fumigatus. Ilicicolin H can be used for the researches of cancer and infection, such as hepatocellular carcinoma (HCC) and C. albicans infection.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 96.7%
- CAS 番号: 12689-26-8
- 分子式: C27H31NO4
- 分子量:433.54
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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PGK1 9.02 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 4T1 | IC50 |
13.84 μM
Compound: 10
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Cytotoxicity against mouse 4T1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against mouse 4T1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38527379] |
| A549 | IC50 |
7.01 μM
Compound: 10
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Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38527379] |
| B16-F10 | IC50 |
21.58 μM
Compound: 10
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Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38527379] |
| CT26 | IC50 |
19.54 μM
Compound: 10
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Cytotoxicity against mouse CT26 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against mouse CT26 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38527379] |
| HCT-116 | IC50 |
10.75 μM
Compound: 10
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Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38527379] |
| MC-38 | IC50 |
19.55 μM
Compound: 10
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Cytotoxicity against mouse MC38 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against mouse MC38 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38527379] |
| MDA-MB-231 | IC50 |
9.98 μM
Compound: 10
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Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38527379] |
| MDA-MB-435 | IC50 |
6.34 μM
Compound: 10
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Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38527379] |
| NCI-H1703 | IC50 |
6.65 μM
Compound: 10
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Cytotoxicity against human NCI-H1703 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human NCI-H1703 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38527379] |
| PC-3 | IC50 |
>50 μM
Compound: 10
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Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38527379] |
| SNB-19 | IC50 |
14.59 μM
Compound: 10
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Cytotoxicity against human SNB-19 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human SNB-19 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38527379] |
Ilicicolin H (1-8 μM, 24 h) induces apoptosis and increases active cleaved fragments of Caspase-3, Caspase-9 levels in HepG2 and Huh7 cells[1].
Ilicicolin H (2-8 μM, 6 h) reduces the levels of HIF-1α induced by CoCl 2 and the phosphorylation levels of PDHK1 at T338 induced by EGF in HepG2 cells[1].
Ilicicolin H (1-8 μM, 6 h) inhibits lactate production and glucose uptake in HepG2 cells[1].
Ilicicolin H shows anti-fungal activity against C. albicans (0.04 to 0.31 μg/mL), other Candida species (0.01 to 5.0 μg/mL), Cryptococcus (MIC = 0.1-1.56 μg/mL) and A. fumigatus (MIC = 0.08 μg/mL)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2 and Huh7 cells
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Concentration:1, 2, 4 and 8 μM
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Incubation Time:24 h
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Result:Increased C-Cas3, C-Cas9, and C-Parp levels.
Increased apoptotic cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C. albicans infected mice models[2]
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Dosage:6.25, 12.5, 25 and 50 mg/kg
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Administration:Orally administration, daily for 2 days
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Result:Reduced C. albicans burden.
化学情報
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CAS 番号 12689-26-8
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性状 Solid
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分子量 433.54
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分子式 C27H31NO4
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Color Light yellow to yellow
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SMILES
O=C1C(C([C@H]2[C@H](/C=C/C)[C@@]3([H])C[C@@H](C)CC[C@]3([H])C(C)=C2)=O)=C(O)C(C4=CC=C(O)C=C4)=CN1
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Structure Classification
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Initial Source
Campylocarpon sp.
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Li M, et al. A novel inhibitor of PGK1 suppresses the aerobic glycolysis and proliferation of hepatocellular carcinoma. Biomed Pharmacother. 2023 Feb;158:114115. [Content Brief]
[2]. Singh SB, et al. Antifungal spectrum, in vivo efficacy, and structure-activity relationship of ilicicolin h. ACS Med Chem Lett. 2012 Sep 7;3(10):814-7. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Ilicicolin H 関連分類
HY-N8540 関連分類
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