Mps1-IN-7
Based on 1 Customer Validation
Mps1-IN-7 is a potent MPS1 inhibitor (IC50 of 0.020 μM) over JNK1 and JNK2 (JNK1 IC50= 0.11 μM, JNK2 IC50=0.22 μM). Mps1-IN-7 inhibit SW620, CAL51, Miapaca-2, RMG1 cell growth with GI50 values of 0.065, 0.068, 0.25, and 0.110 μM,respectively.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.55%
- CAS 番号: 1578244-34-4
- 分子式: C24H29N7O
- 分子量:431.53
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
IC50: 0.020 μM (MSP1)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CAL-27 | GI50 |
0.23 μM
Compound: 34h
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Antiproliferative activity against human CAL27 cells assessed as cell viability after 72 hrs by MTT assay
Antiproliferative activity against human CAL27 cells assessed as cell viability after 72 hrs by MTT assay
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[PMID: 27055065] |
| CAL-51 | GI50 |
0.068 μM
Compound: 34h
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Antiproliferative activity against human CAL51 cells assessed as cell viability after 72 hrs by MTT assay
Antiproliferative activity against human CAL51 cells assessed as cell viability after 72 hrs by MTT assay
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[PMID: 27055065] |
| HCT-116 | GI50 |
0.16 μM
Compound: 34h
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Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by MTT assay
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[PMID: 27055065] |
| HCT-116 | IC50 |
0.059 μM
Compound: 34h
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Inhibition of wild type Myc-ectopic MPS1 (unknown origin) expressed in human HCT116 cells assessed as autophosphorylation at Thr33/Ser37 after 2 hrs by electrochemiluminescence assay in presence of MG132
Inhibition of wild type Myc-ectopic MPS1 (unknown origin) expressed in human HCT116 cells assessed as autophosphorylation at Thr33/Ser37 after 2 hrs by electrochemiluminescence assay in presence of MG132
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[PMID: 27055065] |
| MIA PaCa-2 | GI50 |
0.25 μM
Compound: 34h
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Antiproliferative activity against human MIAPaCa2 cells assessed as cell viability after 72 hrs by MTT assay
Antiproliferative activity against human MIAPaCa2 cells assessed as cell viability after 72 hrs by MTT assay
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[PMID: 27055065] |
| PNT2 | GI50 |
3.95 μM
Compound: 34h
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Antiproliferative activity against human PNT2 cells assessed as cell viability after 72 hrs by MTT assay
Antiproliferative activity against human PNT2 cells assessed as cell viability after 72 hrs by MTT assay
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[PMID: 27055065] |
| RMG-I | GI50 |
0.11 μM
Compound: 34h
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Antiproliferative activity against human RMG-1 cells assessed as cell viability after 72 hrs by MTT assay
Antiproliferative activity against human RMG-1 cells assessed as cell viability after 72 hrs by MTT assay
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[PMID: 27055065] |
| Sf9 | IC50 |
0.011 μM
Compound: 34h
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Inhibition of human full length MPS1 expressed in recombinant baculovirus infected Sf9 insect cells using 5FAM-DHTGFLTEYVATRCONH2 as substrate after 60 to 90 mins
Inhibition of human full length MPS1 expressed in recombinant baculovirus infected Sf9 insect cells using 5FAM-DHTGFLTEYVATRCONH2 as substrate after 60 to 90 mins
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[PMID: 27055065] |
| Sf9 | IC50 |
0.02 μM
Compound: 34h
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Inhibition of human full length MPS1 expressed in recombinant baculovirus infected Sf9 insect cells using 5FAM-DHTGFLTEYVATRCONH2 as substrate after 60 to 90 mins in presence of 1 mM ATP
Inhibition of human full length MPS1 expressed in recombinant baculovirus infected Sf9 insect cells using 5FAM-DHTGFLTEYVATRCONH2 as substrate after 60 to 90 mins in presence of 1 mM ATP
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[PMID: 27055065] |
| SW-620 | GI50 |
0.065 μM
Compound: 34h
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Antiproliferative activity against human SW620 cells assessed as cell viability after 72 hrs by MTT assay
Antiproliferative activity against human SW620 cells assessed as cell viability after 72 hrs by MTT assay
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[PMID: 27055065] |
化学情報
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CAS 番号 1578244-34-4
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性状 Solid
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分子量 431.53
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分子式 C24H29N7O
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Color White to yellow
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SMILES
CC(C)(C)[C@@H](NC1=NC=CC2=CN=C(NC3=CC=C(C4=CN(C)N=C4)C=C3OC)N=C21)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 25 mg/mL (57.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3173 mL | 11.5867 mL | 23.1734 mL | 57.9334 mL |
| 5 mM | 0.4635 mL | 2.3173 mL | 4.6347 mL | 11.5867 mL | |
| 10 mM | 0.2317 mL | 1.1587 mL | 2.3173 mL | 5.7933 mL | |
| 15 mM | 0.1545 mL | 0.7724 mL | 1.5449 mL | 3.8622 mL | |
| 20 mM | 0.1159 mL | 0.5793 mL | 1.1587 mL | 2.8967 mL | |
| 25 mM | 0.0927 mL | 0.4635 mL | 0.9269 mL | 2.3173 mL | |
| 30 mM | 0.0772 mL | 0.3862 mL | 0.7724 mL | 1.9311 mL | |
| 40 mM | 0.0579 mL | 0.2897 mL | 0.5793 mL | 1.4483 mL | |
| 50 mM | 0.0463 mL | 0.2317 mL | 0.4635 mL | 1.1587 mL |
Mps1-IN-7 関連分類
HY-12862 関連分類
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