MYC-IN-4
MYC-IN-4 is a MYC inhibitor. MYC-IN-4 impairs MYC/MAX protein-protein interaction (IC50 = 3.06 μM). MYC-IN-4 inhibits MYC-aberrant PC-3 prostate cancer cells with an IC50 of 0.440 μM. MYC-IN-4 demonstrates potent antitumor efficacy in FVB mice bearing Myc-CaP prostate tumor allografts. MYC-IN-4 can be used for the study of prostate cancer.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3109265-41-7
- 分子式: C19H10F6N2O2
- 分子量:412.29
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
MYC-IN-4 (Compound 15) exhibits potent antiproliferative activity against PC-3 cells (MYC-aberrant prostate cancer cells), with an IC50 value of 0.440 μM[1].
MYC-IN-4 (68 h) shows broad-spectrum antiproliferative activity against 14 other neoplastic cell lines, including MDA-MB-231, HCT-116, Myc-CaP, LN-CaP, NCI-H1581, A549, SK-N-BE, SK-OV-3, HepG-2, A-204, A-431, MG-63, LP-1, and MV4-11 cells, with IC50 values ranging from 0.331 μM to 2.60 μM[1].
MYC-IN-4 (10 μM, 1 h) significantly impairs MYC/MAX protein-protein interaction (PPI) in PC-3 cells via Co-IP assay[1].
MYC-IN-4 (0.1-100 μM, 2 h) inhibits MYC/MAX PPI in a cell-free AlphaLISA assay, with an IC50 value of 3.06 μM[1].
MYC-IN-4 (10 μM, 1 h) reduces the thermal stability of endogenous MYC in PC-3 cells[1].
MYC-IN-4 (1-10 μM, 24 h) induces concentration-dependent MYC degradation in PC-3 cells[1].
MYC-IN-4 suppresses MYC transcriptional activity in HEK293T cells transfected with E-box luciferase reporter plasmid, with an IC50 value of 0.739 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Myc-CaP cells (1 × 106 in 100 µL total volume) were subcutaneously implanted into the right flanks of 6-week-old male FVB mice to establish MYC-driven prostate tumor allograft models[1]
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Dosage:10, 30, 50 mg/kg
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Administration:i.p., QOD for 16 days
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Result:Achieved tumor growth inhibition (TGI) rates of 57% and 70% at doses of 30 mg/kg and 50 mg/kg.
Showed no significant changes in body weight.
Reduced the Ki67 expression.
Combined with INCB086550 (HY-134884) increased the infiltration of CD8⁺ T cells and CD45⁺ leukocytes in the tumor microenvironment.
化学情報
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CAS 番号 3109265-41-7
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分子量 412.29
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分子式 C19H10F6N2O2
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SMILES
OC1=C2C(OC(C3=CC=C(C=C3)C(F)(F)F)=C2)=CC=C1C4=CC(C(F)(F)F)=NN4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MYC-IN-4 関連分類
HY-178045 関連分類
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