PLK4-IN-7
PLK4-IN-7 is a selective and orally active PLK4 inhibitor with an IC50 value of 7.9 nM. PLK4-IN-7 exhibits potent antitumor activity and favorable metabolic stability. PLK4-IN-7 can be used for the research of tumors such as neuroblastoma.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C20H19F6N7O2
- 分子量:503.40
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
|
PLK4 7.9 nM (IC50) |
PLK4-IN-7 (Compound 25) (5 days) can inhibit the viability of CHP-134 neuroblastoma cells, with an EC50 value of 88 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:CHP-134 neuroblastoma tumor-bearing mouse xenograft model[1]
-
Dosage:30 mg/kg, 100 mg/kg
-
Administration:p.o., twice daily for 16 days
-
Result:Was well-tolerated with no significant body weight loss observed during the treatment period, and the final tumor growth inhibition rates were 115% (30 mg/kg group) and 117% (100 mg/kg group), respectively.
化学情報
-
分子量 503.40
-
分子式 C20H19F6N7O2
-
SMILES
O=C(NC1=CNN=C1C2=CC3=C(C=N2)C=NN3CC(F)(F)F)N4C5(C[C@@](C(F)(F)F)(CC4)O)CC5
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PLK4-IN-7 関連分類
HY-180111 関連分類
Powered by Bioz