SARS-CoV-2-IN-27
SARS-CoV-2-IN-27 is a two-armed diphosphate ester with C6 alkyl and molecular tweezers with extended length. SARS-CoV-2-IN-27 exhibits antiviral activity with IC50s of 1.0 μM and 1.7 μM against SARS-CoV-2 activity and the spike pseudoparticle transduction, respectively. SARS-CoV-2-IN-27 induces liposomal membrane disruption with an EC50 value of 6.5 μM.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C54H56O8P2
- 分子量:894.97
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
IC50: 6.5 μM (viral liposome, SARS-CoV-2)[1]
SARS-CoV-2-IN-27 (CP019) inhibits SARS-CoV-2 (IC50=1.7 μM) with few cytotoxicity (Caco2 cells, CC50=208 μM)[1].
SARS-CoV-2-IN-27 (0-15 μM; 2 h) inactivate SARS-CoV-2, shows inhibition against infection with an IC50 value of 1.0 μM[1].
SARS-CoV-2-IN-27 suppresses varies enveloped viruses activity with IC50s of 7.4 μM (respiratory syncytial virus, RSV), 112.6 μM (influenza A virus, IAV), 4.6 μM (measles virus, MeV), 1.8 μM (herpes simplex viruses, HSV-1), respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Caco2 cells exposed with SARS-CoV-2 (2 h, 37 ℃)
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Concentration:0, 0.23, 0.93, 3.75, 15 μM
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Incubation Time:2 hours; determined infection rates on day 2
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Result:Inhibited SARS-CoV-2 infection activity to Caco2 cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Respiratory syncytial virus (RSV) infection of BALB/cJ mice and SARS-CoV-2 infection of K18-hACE2 mice[1]
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Dosage:150 μM, 50 μL
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Administration:Intranasal route; single dose; sacrificed BALB/cJ mice on day 5; treated K18-hACE2 mice once again after 7 h and sacrificed mice on day 2
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Result:Reduced viral load in the lungs of SARS-CoV-2-infected mice.
Completely abolished SARS-CoV-2 infection of all tested mice without changing body weight of mice.
化学情報
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分子量 894.97
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分子式 C54H56O8P2
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SMILES
OP(OC1=C2C(C3C4=C(C2C3)C=C5C(C6C7=C(C5C6)C=CC=C7)=C4)=C(C8=C1C9C%10=CC(C%11CC%12C%13=C%11C=CC=C%13)=C%12C=C%10C8C9)OP(OCCCCCC)(O)=O)(OCCCCCC)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SARS-CoV-2-IN-27 関連分類
HY-151271 関連分類
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