44 Results for "

LL37

" in MedChemExpress (MCE) Product Catalog:
Products (44)

44 Results for "LL37" in MCE Product Catalog:

6
LL-37, human
LL-37, human
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6 Publications Verification
製品番号: HY-P1222
CAS 番号: 154947-66-7
Target:  

Bacterial

研究分野:  

Infection

LL-37, human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human could help protect the cornea from infection and modulates wound healing .
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6
LL-37, human TFA
LL-37, human TFA
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6 Publications Verification
製品番号: HY-P1222A
Target:  

Bacterial

研究分野:  

Infection

LL-37, human TFA is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human TFA could help protect the cornea from infection and modulates wound healing .
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6
LL-37, human acetate
LL-37, human acetate
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6 Publications Verification
製品番号: HY-P1222B
Target:  

Bacterial

研究分野:  

Infection Inflammation/Immunology

LL-37, human acetate is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human acetate could help protect the cornea from infection and modulates wound healing .
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3
Ercalcitriol
Ercalcitriol
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3 Cited Publications
製品番号: HY-32350
CAS 番号: 60133-18-8
別名: 1α,25-Dihydroxy Vitamin D2
Category:  

天然物 Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

VD/VDR Drug Metabolite Endogenous Metabolite

Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases .
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2
LL-37 amide
LL-37 amide
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2 Cited Publications
製品番号: HY-P4744
CAS 番号: 597562-32-8
Target:  

Formyl Peptide Receptor (FPR) Bacterial

研究分野:  

Infection Cancer

LL-37 amide is a selective agonist of formyl peptide receptor-like FPRL1, effectively inhibiting periodontal pathogens (ED99=8.5-8.7 μg/mL). LL-37 amide exerts its bactericidal effect by activating FPRL1-mediated immune cell chemotaxis and disrupting bacterial cell membrane integrity. It can also regulate inflammatory responses (inhibiting the release of factors such as TNF-α) and promote angiogenesis. Amidation modification reduces its sensitivity to serum inhibition and improves its stability. LL-37 amide possesses key activities in bactericidal action, immunomodulation, and wound healing, and is mainly used in research on infection-related diseases such as periodontal disease and deep tissue injuries (pressure ulcers), and wound healing .
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2
LL-37 amide TFA
LL-37 amide TFA
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2 Cited Publications
製品番号: HY-P4744A
Target:  

Formyl Peptide Receptor (FPR) Bacterial

研究分野:  

Infection Cancer

LL-37 amide TFA is a selective agonist of formyl peptide receptor-like FPRL1, effectively inhibiting periodontal pathogens (ED99=8.5-8.7 μg/mL). LL-37 amide TFA exerts its bactericidal effect by activating FPRL1-mediated immune cell chemotaxis and disrupting bacterial cell membrane integrity. It can also regulate inflammatory responses (inhibiting the release of factors such as TNF-α) and promote angiogenesis. Amidation modification reduces its sensitivity to serum inhibition and improves its stability. LL-37 amide TFA possesses key activities in bactericidal action, immunomodulation, and wound healing, and is mainly used in research on infection-related diseases such as periodontal disease and deep tissue injuries (pressure ulcers), and wound healing .
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1
CRAMP (mouse)
CRAMP (mouse)
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1 Cited Publications
製品番号: HY-P4855
CAS 番号: 376364-36-2
Target:  

Bacterial TNF Receptor

研究分野:  

Infection Inflammation/Immunology

CRAMP (mouse) is an antibacterial peptide and a functional homolog of LL-37 . CRAMP (mouse) exhibits potent antibacterial activity against Gram-negative bacteria . The complex formed by CRAMP (mouse) and CpG can activate macrophages to secrete TNF-α . CRAMP (mouse) plays a key role in wound healing, immune regulation and maintenance of intestinal homeostasis .
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1
Tumulosic acid
Tumulosic acid
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1 Cited Publications
製品番号: HY-N9366
CAS 番号: 508-24-7
Category:  

Triterpenes Terpenoids Polyporaceae Poria cocos Plants Disease Research Fields Inflammation/Immunology

Target:  

Others

Tumulosic acid, a triterpenoid, inhibits KLK5 protease activity (IC50= 14.84 μM). Tumulosic acid suppresses the proteolytic processing of LL-37 in keratinocytes at ≤10 μM .
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LL-37 scrambled peptide acetate
LL-37 scrambled peptide acetate
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製品番号: HY-P1513A
Target:  

Bacterial

研究分野:  

Infection

LL-37 scrambled peptide acetate is a scrambled version of cathelicidin anti-microbial peptide LL-37. LL-37 scrambled peptide acetate can be used as a negative control of LL-37 peptide studies.
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LL-37, acetylated,amidated
LL-37, acetylated,amidated
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製品番号: HY-P1884
Target:  

Bacterial

研究分野:  

Infection

LL-37, acetylated, amidated is a cathelicidin peptide LL-37 acetylated on the N-terminus and amidated on the C-terminus. The single human cathelicidin peptide LL-37 has antimicrobial and anti-biofilm activity against multiple Gram-positive and Gram-negative human pathogens, and has wound-healing effects on the host .
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LL-37(17-32)
LL-37(17-32)
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製品番号: HY-P5391
CAS 番号: 717919-61-4
Target:  

BCRP

研究分野:  

Cancer

LL-37 (17-32) is an ABCG2 inhibitor. LL-37 (17-32) binds to ABCG2, inhibits its transport activity in a non-competitive manner, and downregulates ABCG2 protein expression via lysosomal degradation. LL-37 (17-32) increases the accumulation of Mitoxantrone (HY-13502) in cancer cells overexpressing ABCG2, thereby reversing mitoxantrone resistance. LL-37 (17-32) can be used in the research of multidrug-resistant cancers .
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LL-37 SKE
LL-37 SKE
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製品番号: HY-P4128
CAS 番号: 1072128-56-3
Target:  

Bacterial Antibiotic

研究分野:  

Others

LL-37 SKE is an active fragment of LL-37 .
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KR-12 (human)
KR-12 (human)
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製品番号: HY-P10257
CAS 番号: 1218951-51-9
Target:  

Bacterial

研究分野:  

Infection

KR-12 (human) is an active segment of LL-37 (HY-P4744). KR-12 (human) exhibits antimicrobial activity against gram-negative bacteria. KR-12 (human) inhibits E. coli K-12 with a MIC of 66 μM. KR-12 human can be used for the research of infection, such as E. coli infection .
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LL-37 FK-13 TFA
LL-37 FK-13 TFA
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製品番号: HY-P4836A
Target:  

Parasite

研究分野:  

Infection

LL-37 FK-13 TFA is the TFA salt form of LL-37 FK-13 (HY-P4836). LL-37 FK-13 TFA is an antimicrobial agent, that inhibits Trichomonas vaginalis. LL-37 FK-13 TFA exhibits minimal hemolytic effects on human erythrocytes and low cytotoxicity to human fibroblasts .
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LL-37 scrambled peptide
LL-37 scrambled peptide
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製品番号: HY-P1513
Target:  

Bacterial

研究分野:  

Infection

LL-37 scrambled peptide is a scrambled version of cathelicidin anti-microbial peptide LL-37. LL-37 scrambled peptide can be used as a negative control of LL-37 peptide studies.
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Polymyxin B2
Polymyxin B2
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製品番号: HY-A0248B
CAS 番号: 34503-87-2
Target:  

Antibiotic Bacterial

研究分野:  

Infection Inflammation/Immunology

Polymyxin B2 is a polypeptide antibiotic with particularly potent antibacterial activity against Gram-negative bacteria. Polymyxin B2 kills bacteria by binding to lipopolysaccharide molecules on the bacterial cell membrane, disrupting membrane integrity and causing leakage of intracellular contents. Polymyxin B2 is used in studies related to Pseudomonas aeruginosa infection and acute enteritis .
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5-FAM-LL-37 TFA
5-FAM-LL-37 TFA
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製品番号: HY-P5057A
Target:  

Fluorescent Dye Bacterial

研究分野:  

Infection

5-FAM-LL-37 TFA is the TFA salt form of 5-FAM-LL-37 (HY-P5057). 5-FAM-LL-37 TFA is a LL-37 peptide labeled with fluorescein, which retains the antibacterial and immunomodulatory activities of LL-37. 5-FAM-LL-37 TFA binds to the bacterial cell membrane, destroys the integrity of the membrane, and exhibits board-spectrum antibacterial efficacy .
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LL-37 (37-1)
LL-37 (37-1)
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製品番号: HY-P4741
CAS 番号: 2022972-70-7
Target:  

ペプチド

研究分野:  

Others

LL-37 (37-1) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
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LL-37 GKE
LL-37 GKE
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製品番号: HY-P4747
CAS 番号: 913736-92-2
Target:  

Antibiotic Bacterial

研究分野:  

Infection

LL-37 GKE is an active domain of LL-37. LL-37 GKE has antibacterial activity and has potential applications in antibiotics .
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LL-37 FK-13
LL-37 FK-13
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製品番号: HY-P4836
CAS 番号: 717919-68-1
Target:  

Parasite

研究分野:  

Infection

LL-37 FK-13 is an antimicrobial agent, that inhibits Trichomonas vaginalis. LL-37 FK-13 exhibits slight hemolytic effects on human erythrocytes and low cytotoxicity to human fibroblasts .
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