376364-36-2
Chemical Structure
CRAMP (mouse)
- CAS No.: 376364-36-2
- Formula:C178H302N50O46
- Molecular Weight:3878.61
SMILES: O=C(CN)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCC(N)=O)=O)CCC(O)=O)=O)CCC2)=O)CCC(N)=O)=O)CCC1)=O)C(C)C)=O)CC(C)C)=O)CCCCN)=O)CCC(N)=O)=O)CC3=CC=CC=C3)=O)CC4=CC=CC=C4)=O)CC(N)=O)=O)CCCCN)=O)[C@H](CC)C)=O)CCCCN)=O)CCC(N)=O)=O)=O)[C@H](CC)C)=O)CCCCN)=O)CCCCN)=O)CC(C)C)=O)CCCCN)=O)CCC(O)=O)=O)=O)[C@H](CC)C)=O)CCCCN)=O)CCC(O)=O)=O)=O)=O)CCCCN)=O)CCCNC(N)=N)=O)CC(C)C)=O)CC(C)C
Biological Activity: CRAMP (mouse) is an antibacterial peptide and a functional homolog of LL-37. CRAMP (mouse) exhibits potent antibacterial activity against Gram-negative bacteria. The complex formed by CRAMP (mouse) and CpG can activate macrophages to secrete TNF-α. CRAMP (mouse) plays a key role in wound healing, immune regulation and maintenance of intestinal homeostasis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CRAMP (mouse) | 98.97% | CRAMP (mouse) is an antibacterial peptide and a functional homolog of LL-37. CRAMP (mouse) exhibits potent antibacterial activity against Gram-negative bacteria. The complex formed by CRAMP (mouse) and CpG can activate macrophages to secrete TNF-α. CRAMP (mouse) plays a key role in wound healing, immune regulation and maintenance of intestinal homeostasis. | ||||||||||||||||||||
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References
- [1]. De Brucker K, et al. Derivatives of the mouse cathelicidin-related antimicrobial peptide (CRAMP) inhibit fungal and bacterial biofilm formation. Antimicrob Agents Chemother. 2014;58(9):5395-5404. [Content Brief]
- [2]. Wong A, et al. A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA. J Immunol. 2018;200(7):2327-2340. [Content Brief]
