1. Immunology/Inflammation
  2. PD-1/PD-L1
  3. AUNP-12

AUNP-12 (Synonyms: NP-12)

Cat. No.: HY-P1812
Handling Instructions

AUNP-12 (NP-12) is a peptide antagonist of the PD-1 signaling pathway, displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions. AUNP-12 exhibits immune activation, excellent antitumor activity, and potential for better management of immune-related adverse events (irAEs).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

AUNP-12 Chemical Structure

AUNP-12 Chemical Structure

CAS No. : 1353563-85-5

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Description

AUNP-12 (NP-12) is a peptide antagonist of the PD-1 signaling pathway, displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions. AUNP-12 exhibits immune activation, excellent antitumor activity, and potential for better management of immune-related adverse events (irAEs)[1].

IC50 & Target

PD-1 signaling pathway[1]

In Vitro

AUNP-12 displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions [1].
AUNP-12 rescues the proliferation in the mouse splenocyte assay system, with average EC50 values of 17 nM and 16.6 nM against rmPD-L1 and rmPD-L2 respectively[1].
AUNP-12 is also able to significantly rescue recombinant human PD-L1 and PD-L2 mediated inhibition of in vitro human PBMC proliferation, with average EC50 values of 63.3 nM and 44.1 nM against PD-L1 and PD-L2 respectively[1].

Molecular Weight

3261.55

Formula

C₁₄₂H₂₂₆N₄₀O₄₈

CAS No.

1353563-85-5

Sequence

Ser-Asn-Thr-Ser-Glu-Ser-Phe-Lys(Ser-Asn-Thr-Ser-Glu-Ser-Phe)-Phe-Arg-Val-Thr-Gln -Leu-Ala-Pro-Lys-Ala-Gln-Ile-Lys-Glu-NH2

Sequence Shortening

H-SNTSESFKF(H-SNTSESF)RVTQLAPKAQIKE-NH2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AUNP-12NP-12AUNP12AUNP 12NP12NP 12PD-1/PD-L1PD-1/Programmed death-ligand 1PD-1PD-L1PD-L2irAEsInhibitorinhibitorinhibit

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AUNP-12
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