1. Immunology/Inflammation
  2. PD-1/PD-L1
  3. NP-12 (TFA)

NP-12 (TFA) 

Cat. No.: HY-P1812A Purity: >96.0%
Handling Instructions

NP-12 (TFA) is a peptide antagonist of the PD-1 signaling pathway, displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions. NP-12 (TFA) exhibits immune activation, excellent antitumor activity, and potential for better management of immune-related adverse events (irAEs).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

NP-12 (TFA) Chemical Structure

NP-12 (TFA) Chemical Structure

Size Price Stock Quantity
1 mg USD 160 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 615 In-stock
Estimated Time of Arrival: December 31
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100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of NP-12 (TFA):

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Description

NP-12 (TFA) is a peptide antagonist of the PD-1 signaling pathway, displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions. NP-12 (TFA) exhibits immune activation, excellent antitumor activity, and potential for better management of immune-related adverse events (irAEs)[1].

IC50 & Target

PD-1 signaling pathway[1]

Molecular Weight

3375.63

Formula

C₁₄₄H₂₂₇F₃N₄₀O₅₀

Sequence

Ser-Asn-Thr-Ser-Glu-Ser-Phe-Lys(Ser-Asn-Thr-Ser-Glu-Ser-Phe)-Phe-Arg-Val-Thr-Gln -Leu-Ala-Pro-Lys-Ala-Gln-Ile-Lys-Glu-NH2

Sequence Shortening

H-SNTSESFKF(H-SNTSESF)RVTQLAPKAQIKE-NH2

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >96.0%

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NP-12 (TFA)
Cat. No.:
HY-P1812A
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