Tumulosic acid
Based on 1 publication(s) in Google Scholar
Tumulosic acid, a triterpenoid, inhibits KLK5 protease activity (IC50= 14.84 μM). Tumulosic acid suppresses the proteolytic processing of LL-37 in keratinocytes at ≤10 μM.
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- 純度: 98.66%
- CAS 番号: 508-24-7
- 分子式: C31H50O4
- 分子量:486.73
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Tumulosic acid
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生物活性
Tumulosic acid displays dose-dependent anti-KLK5 activity (IC50=19.3 μM)[1].
Tumulosic acid decreases in LL-37 production in human keratinocytes[1].
Tumulosic acid shows IC50 values of 14.84 and 10.48 μM against KLK5 and trypsin proteases, while it exhibited a weak inhibitory effect on KLK7 and chymotrypsin C proteases (19.5% and 4.0%, respectively, at 100 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Normal human epidermal keratinocytes (NHEKs)
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Concentration:1 μM and 10 μM
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Incubation Time:23 h in the presence of 10 μM cycloheximide
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Result:Decreased LL-37 production in epidermal keratinocytes.
化学情報
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CAS 番号 508-24-7
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性状 Solid
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分子量 486.73
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分子式 C31H50O4
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Color White to off-white
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SMILES
C[C@@](C(CC[C@](C(C)1C)([H])[C@@]2(CC[C@@H]1O)C)=C2CC3)(C[C@H]4O)[C@]3([C@@]4([H])[C@H](C(O)=O)CCC(C(C)C)=C)C
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Sci Signal
The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation. [Abstract]2024 Aug 20;17(850):eadn3785. PMID: 39163389
溶剤 & 溶解度
DMSO : 25 mg/mL (51.36 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0545 mL | 10.2726 mL | 20.5453 mL | 51.3632 mL |
| 5 mM | 0.4109 mL | 2.0545 mL | 4.1091 mL | 10.2726 mL | |
| 10 mM | 0.2055 mL | 1.0273 mL | 2.0545 mL | 5.1363 mL | |
| 15 mM | 0.1370 mL | 0.6848 mL | 1.3697 mL | 3.4242 mL | |
| 20 mM | 0.1027 mL | 0.5136 mL | 1.0273 mL | 2.5682 mL | |
| 25 mM | 0.0822 mL | 0.4109 mL | 0.8218 mL | 2.0545 mL | |
| 30 mM | 0.0685 mL | 0.3424 mL | 0.6848 mL | 1.7121 mL | |
| 40 mM | 0.0514 mL | 0.2568 mL | 0.5136 mL | 1.2841 mL | |
| 50 mM | 0.0411 mL | 0.2055 mL | 0.4109 mL | 1.0273 mL |
Tumulosic acid 関連分類
HY-N9366 関連分類
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