717919-61-4
Chemical Structure
LL-37(17-32)
- CAS No.: 717919-61-4
- Formula:C95H161N29O21
- Molecular Weight:2045.48
SMILES: O=C([C@@H](N)CC1=CC=CC=C1)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)C(C)C)=O)CC(C)C)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)CC2=CC=CC=C2)=O)CC(O)=O)=O)CCCCN)=O)[C@H](CC)C)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)C(C)C)=O)[C@H](CC)C)=O)CCCNC(N)=N)=O)CCCCN
Biological Activity: LL-37 (17-32) is an ABCG2 inhibitor. LL-37 (17-32) binds to ABCG2, inhibits its transport activity in a non-competitive manner, and downregulates ABCG2 protein expression via lysosomal degradation. LL-37 (17-32) increases the accumulation of Mitoxantrone (HY-13502) in cancer cells overexpressing ABCG2, thereby reversing mitoxantrone resistance. LL-37 (17-32) can be used in the research of multidrug-resistant cancers[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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LL-37(17-32) | 96.71% | LL-37 (17-32) is an ABCG2 inhibitor. LL-37 (17-32) binds to ABCG2, inhibits its transport activity in a non-competitive manner, and downregulates ABCG2 protein expression via lysosomal degradation. LL-37 (17-32) increases the accumulation of Mitoxantrone (HY-13502) in cancer cells overexpressing ABCG2, thereby reversing mitoxantrone resistance. LL-37 (17-32) can be used in the research of multidrug-resistant cancers. | ||||||||||||||||||||
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Keywords
