STAT3-IN-38
STAT3-IN-38 (Compound 4m) is an inhibitor of STAT3 (KD of rhSTAT3: 45.33 µM). STAT3-IN-38 binds to the SH2 domain of STAT3 protein and suppresses the STAT3’s phosphorylation at site pTyr705 as well as its downstream genes (Survivin and Mcl-1). STAT3-IN-38 could block cell-cycle and induce Apoptosis in colorectal cancer cells.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3033049-16-7
- 分子式: C35H45NO3S
- 分子量:559.80
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
|
STAT3 45.33 μM (Kd) |
STAT3-IN-38 (0.5-1 μM, 6 h) inhibits the phosphorylation of STAT3 and decreases levels of the STAT3 target proteins survivin and myeloid cell leukemia 1 (Mcl-1) in HCT116 cells[1].
STAT3-IN-38 (0.02-12.5 μM, 48 h) inhibits the proliferation of A549, HCT116, and HepG2 cells[1].
STAT3-IN-38 (1-5 μM, 48 h) induces apoptosis and cell cycle arrest in HCT116 cells[1].
STAT3-IN-38 (1-10 µM, 6 days) reduces the viability of human colorectal cancer organoids (CCOs)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HCT-116
-
Concentration:1, 2.5, 5 μM
-
Incubation Time:48 h
-
Result:Delayed cell cycle distribution, with a leading cell cycle arrest in G2/M phase at low concentrations and in S and G2/M phases at high concentrations.
-
Cell Line:A549、HCT-116、HepG2
-
Concentration:0.02, 0.1, 0.5, 2.5, 12.5 μM
-
Incubation Time:48 h
-
Result:Inhibited the proliferation of A549, HCT116, and HepG2 cells (IC50s = 0.93, 0.61, and 1.79 µM, respectively).
-
Cell Line:HCT-116
-
Concentration:0.5, 0.75, 1 μM
-
Incubation Time:6 h
-
Result:Decreased the level of p-STAT3 at site pTyr705 in a concentration dependent manner, and the function was stronger than celastrol at 1.0 μM.
Down-regulated the level of Survivin and Mcl-1.
化学情報
-
CAS 番号 3033049-16-7
-
分子量 559.80
-
分子式 C35H45NO3S
-
SMILES
C[C@@]12[C@]([C@@]3([H])[C@@](CC1)(CC[C@](C)(C3)C(NCCC4=CC=CS4)=O)C)(CC[C@@]5(C2=CC=C6C5=CC(C(O)=C6C)=O)C)C
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
STAT3-IN-38 関連分類
HY-169797 関連分類
Powered by Bioz