Thiomandelic acid
Based on 1 Customer Validation
Thiomandelic acid is a broad spectrum inhibitor of Zinc -lactamases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 95.37%
- CAS 番号: 4695-09-4
- 分子式: C8H8O2S
- 分子量:168.21
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Beta-lactamase アイソフォーム固有の製品をすべて表示
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生物活性
Thiomandelic acid is found to be a reasonably potent (submicromolar) inhibitor for all of the MBLs tested, except for the subclass B2 enzyme from A. hydrophila (CphA)[1].
Thiomandelic Acid binds to both metal ions in metallo-β-lactamase and induces positive cooperativity in metal binding[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 4695-09-4
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性状 Solid
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分子量 168.21
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分子式 C8H8O2S
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Color White to off-white
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SMILES
O=C(O)C(S)C1=CC=CC=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 250 mg/mL (1486.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. C Mollard, et al. Thiomandelic acid, a broad spectrum inhibitor of zinc beta-lactamases: kinetic and spectroscopic studies. J Biol Chem. 2001 Nov 30;276(48):45015-23. [Content Brief]
[2]. Christian Damblon, et al. The inhibitor thiomandelic acid binds to both metal ions in metallo-beta-lactamase and induces positive cooperativity in metal binding. J Biol Chem. 2003 Aug 1;278(31):29240-51. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.9449 mL | 29.7247 mL | 59.4495 mL | 148.6237 mL |
| 5 mM | 1.1890 mL | 5.9449 mL | 11.8899 mL | 29.7247 mL | |
| 10 mM | 0.5945 mL | 2.9725 mL | 5.9449 mL | 14.8624 mL | |
| 15 mM | 0.3963 mL | 1.9816 mL | 3.9633 mL | 9.9082 mL | |
| 20 mM | 0.2972 mL | 1.4862 mL | 2.9725 mL | 7.4312 mL | |
| 25 mM | 0.2378 mL | 1.1890 mL | 2.3780 mL | 5.9449 mL | |
| 30 mM | 0.1982 mL | 0.9908 mL | 1.9816 mL | 4.9541 mL | |
| 40 mM | 0.1486 mL | 0.7431 mL | 1.4862 mL | 3.7156 mL | |
| 50 mM | 0.1189 mL | 0.5945 mL | 1.1890 mL | 2.9725 mL | |
| 60 mM | 0.0991 mL | 0.4954 mL | 0.9908 mL | 2.4771 mL | |
| 80 mM | 0.0743 mL | 0.3716 mL | 0.7431 mL | 1.8578 mL | |
| 100 mM | 0.0594 mL | 0.2972 mL | 0.5945 mL | 1.4862 mL |
Thiomandelic acid 関連分類
HY-129629 関連分類
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