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製品番号: HY-153501

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TrkA-IN-5

TrkA-IN-5 is a TrkA inhibitor with an IC₅₀ value of 1.678 nM against TrkA. TrkA-IN-5 can be used in cancer research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1377503-70-2
分子式: C₂₅H₁₈F₃N₅O₂S
分子量:509.51

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

TrkA-IN-5 構造式

CAS 番号: 1377503-70-2

容量

価格（税別）

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数量

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

TrkA-IN-5 is a TrkA inhibitor with an IC₅₀ value of 1.678 nM against TrkA. TrkA-IN-5 can be used in cancer research^[1].

IC₅₀ & Target^[1]

TrkA

1.678 nM (IC₅₀)

Trk Receptor アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	GI	40 % Compound: 6t	Cytotoxicity against human MCF7 cells assessed as growth inhibition at 0.1 to 50 uM after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as growth inhibition at 0.1 to 50 uM after 48 hrs by MTT assay	[PMID: 22575050]
MCF7	IC₅₀	4.2 μM Compound: 6t	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 22575050]

体外実験

TrkA-IN-5 (Compound 20) potently inhibits human TrkA (PDB ID: 4aoj) with an IC₅₀ value of 1.678 nM. It forms multiple stable hydrogen bonds and hydrophobic interactions with the active site of this protein, and its activity can be accurately predicted by CoMFA and CoMSIA 3D-QSAR models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1377503-70-2
分子量 509.51
分子式 C₂₅H₁₈F₃N₅O₂S
SMILES

O=S(=O)(NC1=CC(N)=CC(=C1)C2=CN=C3NC=C(C=4C=CN=CC4)C3=C2)C=5C=CC=C(C5)C(F)(F)F
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Adnane Aouidate, et al. Molecular Docking and 3D-QSAR Studies on 7-azaindole Derivatives as
Inhibitors of Trk A: A Strategic Design in Novel Anticancer Agents. Letters in Drug Design & Discovery, 2018, 15, 1211-1223.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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TrkA-IN-5

Trk Receptor アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

TrkA-IN-5 関連分類

HY-153501 関連分類