1. Cell Cycle/DNA Damage
    Apoptosis
  2. IRE1
    Apoptosis
  3. KIRA9

KIRA9 

Cat. No.: HY-145422
Handling Instructions

KIRA9 is a potent IRE1 inhibitor (IC50=4.8 μM in INS-1 cells). KIRA9 is able to fully engage the ATP-binding site of IRE1α. KIRA9 can block ER-localized mRNA decay and apoptosis.

For research use only. We do not sell to patients.

KIRA9 Chemical Structure

KIRA9 Chemical Structure

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Description

KIRA9 is a potent IRE1 inhibitor (IC50=4.8 μM in INS-1 cells). KIRA9 is able to fully engage the ATP-binding site of IRE1α. KIRA9 can block ER-localized mRNA decay and apoptosis[1].

IC50 & Target

IC50: 4.8 μM (IRE1) in INS-1 cells[1]

In Vitro

KIRA9 (0-30 μM; 2 hours) blocks the autophosphorylation induced by conditional overexpression of IRE1α in INS-1 cells (IC50=4.8 μM)[1].
KIRA9 (20 μM; 2 hours) reduces the mRNA expression of Bloc1s1, Ins1 and Ins2 in INS-1 cells[1].
KIRA9 (20 μM; 2 hours) blunts IRE1α-dependent decay (RIDD) in ER-stressed INS-1 cells[1].
KIRA9 (20 μM; 1 hour) markedly reduces the generation of cleaved caspase-3 and shows significant cytoprotective efficacy[1].
KIRA9 (0-20 μM; 3 days) reduces XBP1s expression, plasma cell differentiation and IgM secretion in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis

Cell Line: INS-1 cells[1]
Concentration: 20 μM
Incubation Time: 1 hour
Result: Markedly reduced the generation of cleaved caspase-3 and showed significant cytoprotective efficacy.

Cell Differentiation Assay

Cell Line: Mouse splenocytes (LPS-treated)[1]
Concentration: 0, 1.25, 2.5, 5.0, 10 and 20 μM
Incubation Time: 3 days
Result: Reduced XBP1s expression, plasma cell differentiation and IgM secretion in a dose-dependent manner.
Molecular Weight

572.60

Formula

C27H27F3N6O3S

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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KIRA9
Cat. No.:
HY-145422
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