2922507-65-9
2922507-65-9
Chemical Structure
KIRA9
- CAS No.: 2922507-65-9
- Formula:C27H27F3N6O3S
- Molecular Weight:572.60
IUPAC Name: (S)-3,3,3-trifluoro-N-(4-((3-(2-(piperidin-3-ylamino)pyrimidin-4-yl)pyridin-2-yl)oxy)naphthalen-1-yl)propane-1-sulfonamide
InChIKey: HLEZGQAFDDCWDE-SFHVURJKSA-N
SMILES: O=S(NC1=CC=C(OC2=NC=CC=C2C3=CC=NC(N[C@@H]4CNCCC4)=N3)C5=C1C=CC=C5)(CCC(F)(F)F)=O
Biological Activity: KIRA9 is a potent IRE1 inhibitor (IC50=4.8 μM in INS-1 cells). KIRA9 is able to fully engage the ATP-binding site of IRE1α. KIRA9 can block ER-localized mRNA decay and apoptosis[1].
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KIRA9 | KIRA9 is a potent IRE1 inhibitor (IC50=4.8 μM in INS-1 cells). KIRA9 is able to fully engage the ATP-binding site of IRE1α. KIRA9 can block ER-localized mRNA decay and apoptosis. | |||||||||||||||||||||
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References
Keywords
