TMPRSS4 - transmembrane serine protease 4 Gene

Also Known as CAP2; CAPH2; MT-SP2; TMPRSS3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 56649

About TMPRSS4

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:118,077,078-118,125,505 (from NCBI)

This gene has 19 transcripts (splice variants), 148 orthologues, 12 paralogues and is associated with 1 phenotype. Biased expression in colon (RPKM 31.0), urinary bladder (RPKM 28.2) and 8 other tissues.

Summary

This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. The protein has been found to promote SARS-CoV-2 entry into host cells. [provided by RefSeq, Aug 2021]

TMPRSS4 Products (6)

mRNA	Protein	Name
NM_001083947.2	NP_001077416.2	transmembrane protease serine 4 isoform 3
NM_001173551.2	NP_001167022.2	transmembrane protease serine 4 isoform 4
NM_001173552.2	NP_001167023.2	transmembrane protease serine 4 isoform 5
NM_001290094.2	NP_001277023.2	transmembrane protease serine 4 isoform 6
NM_001290096.2	NP_001277025.2	transmembrane protease serine 4 isoform 7
NM_019894.4	NP_063947.2	transmembrane protease serine 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables serine-type peptidase activity	IDA IDA: Inferred from direct assay	24434139	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within negative regulation of growth rate	IDA IDA: Inferred from direct assay	29529050	GOA
involved in positive regulation of viral entry into host cell	IDA IDA: Inferred from direct assay	32404436	GOA
involved in protein processing	IDA IDA: Inferred from direct assay	24434139	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	24434139	GOA
acts upstream of or within regulation of gene expression	IDA IDA: Inferred from direct assay	29529050	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	24434139	GOA
located in secretory granule	IDA IDA: Inferred from direct assay	29529050	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMPRSS4 Protein Structure

SRCR_2

Trypsin

0
100
200
300
400
437 a.a.

Protein Preferred Names	Protein Names
transmembrane protease serine 4	channel-activating protease 2

TMPRSS4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TMPRSS4	Q9NRS4	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	TMPRSS4	Q9NRS4	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	TMPRSS4	Q9NRS4	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	TMPRSS4	Q9NRS4	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	TMPRSS4	Q9NRS4	RASGRP4	Homo sapiens	Q8TDF6-2	Y2H Array	32296183
Intra	TMPRSS4	Q9NRS4	RASGRP4	Homo sapiens	Q8TDF6-2	Y2H Prey Pooling	32296183
Intra	TMPRSS4	Q9NRS4	CLRN1	Homo sapiens	P58418	Y2H Prey Pooling	32296183
Intra	TMPRSS4	Q9NRS4	CLRN1	Homo sapiens	P58418	Y2H Array	32296183
Intra	TMPRSS4	Q9NRS4	SIGLEC12	Homo sapiens	Q96PQ1	Y2H Prey Pooling	32296183
Intra	TMPRSS4	Q9NRS4	SIGLEC12	Homo sapiens	Q96PQ1	Y2H Array	32296183
Intra	TMPRSS4	Q9NRS4	ERVFRD-1	Homo sapiens	P60508	Y2H Prey Pooling	32296183
Intra	TMPRSS4	Q9NRS4	ERVFRD-1	Homo sapiens	P60508	Y2H Array	32296183
Intra	TMPRSS4	Q9NRS4	SUSD3	Homo sapiens	Q96L08	Y2H Prey Pooling	32296183
Intra	TMPRSS4	Q9NRS4	SUSD3	Homo sapiens	Q96L08	Y2H Array	32296183
Intra	TMPRSS4	Q9NRS4	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	TMPRSS4	Q9NRS4	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	TMPRSS4	Q9NRS4	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	25416956
Intra	TMPRSS4	Q9NRS4	BNIP3L	Homo sapiens	O60238	Y2H Array	32296183
Intra	TMPRSS4	Q9NRS4	BNIP3L	Homo sapiens	O60238	Y2H Prey Pooling	32296183
Intra	TMPRSS4	Q9NRS4	CSNK1D	Homo sapiens	P48730-2	Validated Y2H	32814053
Intra	TMPRSS4	Q9NRS4	CSNK1D	Homo sapiens	P48730-2	Y2H Array	32814053
Intra	TMPRSS4	Q9NRS4	CSNK1D	Homo sapiens	P48730-2	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

TMPRSS4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89692	TMPRSS4 Antibody (YA9036)	WB, ICC/IF, IF-Tissue, IP, ELISA	human

Related Diseases

Diseases	Alias
Autosomal Recessive Cerebral Atrophy
Deafness, Autosomal Recessive 8	Neurosensory Nonsyndromic Recessive Deafness 8 DFNB8 Dfnb10 Deafness, Autosomal Recessive 10 Deafness, Childhood-Onset Neurosensory, Autosomal Recessive 8 Nsrd8 Autosomal Recessive Nonsyndromic Deafness 8 Deafness, Autosomal Recessive 8/10 Autosomal Recessive Deafness 10 Autosomal Recessive Deafness 8 Childhood-Onset Neurosensory Autosomal Recessive Deafness 8 Nrsd8 Deafness, Autosomal Recessive, 8 Childhood-Onset Neurosensory Deafness Autosomal Recessive 8 Deafness Autosomal Recessive 10 Deafness Autosomal Recessive 8/10 Deafness Neurosensory Autosomal Recessive 8 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 8 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 8 Deafness, Autosomal Recessive, Type 8/10
Covid-19	2019 Novel Coronavirus 2019-Ncov Infection Covid19 Sars-Cov-2 Infection Wuhan Coronavirus Infection Wuhan Seafood Market Pneumonia Virus Infection
Colorectal Cancer, Hereditary Nonpolyposis, Type 8	HNPCC8 Hereditary Nonpolyposis Colorectal Cancer Type 8 Hereditary Non-Polyposis Colorectal Cancer 8 Cancer, Colorectal, Nonpolyposis, Hereditary, Type 8
Deafness, Autosomal Recessive 98	DFNB98 Autosomal Recessive Nonsyndromic Deafness 98 Autosomal Recessive Deafness 98 Deafness, Autosomal Recessive, 98 Deafness, Autosomal Recessive, Type 98
Deafness, Autosomal Recessive 4, With Enlarged Vestibular Aqueduct	Enlarged Vestibular Aqueduct DFNB4 Neurosensory Nonsyndromic Recessive Deafness 4 Enlarged Vestibular Aqueduct Syndrome Nsrd4 Autosomal Recessive Nonsyndromic Deafness 4 Dilated Vestibular Aqueduct Dva Enlarged Vestibular Aqueduct, Digenic Autosomal Recessive Deafness 4 With Enlarged Vestibular Aqueduct Large Vestibular Aqueduct Syndrome Deafness, Autosomal Recessive, 4 Deafness Neurosensory Autosomal Recessive 4 Eva Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 4 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 4 Deafness, Autosomal Recessive, Type 4 , With Enlarged Vestibular Aqueduct
Deafness, Autosomal Recessive 39	DFNB39 Autosomal Recessive Nonsyndromic Deafness 39 Autosomal Recessive Deafness 39 Deafness, Autosomal Recessive, 39 Congenital Neurosensory Deafness Autosomal Recessive 39 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 39 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 39 Deafness, Autosomal Recessive, Type 39
Deafness, Autosomal Recessive 83	DFNB83 Autosomal Recessive Nonsyndromic Deafness 83 Autosomal Recessive Deafness 83
Deafness, Autosomal Recessive 77	DFNB77 Autosomal Recessive Nonsyndromic Deafness 77 Autosomal Recessive Deafness 77 Deafness, Autosomal Recessive, 77 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 77 Deafness, Autosomal Recessive, Type 77
Petroclival Meningioma
Deafness, Autosomal Recessive 61	DFNB61 Autosomal Recessive Nonsyndromic Deafness 61 Autosomal Recessive Deafness 61 Deafness, Autosomal Recessive, 61 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 61 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 61 Deafness, Autosomal Recessive, Type 61
Deafness, Autosomal Recessive 42	DFNB42 Autosomal Recessive Nonsyndromic Deafness 42 Autosomal Recessive Deafness 42 Deafness, Autosomal Recessive, 42 Congenital Neurosensory Deafness Autosomal Recessive 42 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 42 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 42 Deafness, Autosomal Recessive, Type 42
Auditory System Disease	Ear Diseases Ear And Mastoid Disease
Deafness, Autosomal Recessive 12	DFNB12 Deafness, Autosomal Recessive 12, Modifier Of Autosomal Recessive Nonsyndromic Deafness 12 Autosomal Recessive Deafness 12 Deafness, Autosomal Recessive, 12 Congenital Neurosensory Deafness Autosomal Recessive 12 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 12 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 12 Deafness, Autosomal Recessive, Type 12
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Autosomal Recessive Nonsyndromic Deafness	Deafness, Autosomal Recessive, Nonsyndromic
Cataract 44	CTRCT44 Total Early-Onset Cataract Cataract 44 And Hypotrichosis Cataract And Hypotrichosis Cataract, Type 44
Autosomal Dominant Nonsyndromic Deafness	Autosomal Dominant Deafness
Usher Syndrome Type 2	Ush2 Usher Syndrome Type Ii
Usher Syndrome	Deafness-Retinitis Pigmentosa Syndrome Dystrophia Retinae Pigmentosa-Dysostosis Syndrome Graefe-Usher Syndrome Hallgren Syndrome Usher'S Syndrome Retinitis Pigmentosa-Deafness Syndrome Retinitis Pigmentosa-Hearing Loss Syndrome Ush Usher Syndromes
Sensorineural Hearing Loss	Sensory Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss Disorder Hearing Loss, Sensorineural Central Hearing Loss High Frequency Deafness High Frequency Hearing Loss High-Frequency Hearing Loss Perceptive Deafness Perceptive Hearing Loss Perceptive Hearing Loss Or Deafness Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss High-Frequency Hearing Loss, Central Hearing Loss, High-Frequency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14771	TMPRSS4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18442	Tmprss4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24924	Tmprss4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TMPRSS4	VGNC	VGNC:47634
Felis catus	TMPRSS4	VGNC	VGNC:66387
Bos taurus	TMPRSS4	VGNC	VGNC:36142
Macaca mulatta	TMPRSS4	VGNC	VGNC:78577
Rattus norvegicus	TMPRSS4	RGD	RGD:1305033
Mus musculus	TMPRSS4	MGD	MGI:2384877
Others	TMPRSS4	NCBI