RRM2 - ribonucleotide reductase regulatory subunit M2 Gene

Also Known as R2; RR2; RR2M; C2orf48

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6241

About RRM2

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:10,122,568-10,211,010 (from NCBI)

This gene has 17 transcripts (splice variants), 258 orthologues and 1 paralogue. Biased expression in bone marrow (RPKM 28.1), lymph node (RPKM 20.5) and 13 other tissues.

Summary

This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]

RRM2 Products (2)

mRNA	Protein	Name
NM_001034.4	NP_001025.1	ribonucleoside-diphosphate reductase subunit M2 isoform 2
NM_001165931.1	NP_001159403.1	ribonucleoside-diphosphate reductase subunit M2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17726094	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in 2'-deoxyribonucleotide biosynthetic process	IDA IDA: Inferred from direct assay	16376858	GOA
involved in positive regulation of G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	24253041	GOA
involved in ribonucleoside diphosphate metabolic process	IDA IDA: Inferred from direct assay	16376858	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	18997010	GOA
part of ribonucleoside-diphosphate reductase complex	IPI IPI: Inferred from physical interaction	22632967	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RRM2 Protein Structure

Ribonuc_red_sm

0
100
200
300
389 a.a.

Protein Preferred Names	Protein Names
ribonucleoside-diphosphate reductase subunit M2	ribonucleotide reductase M2 polypeptide

RRM2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RRM2	P31350	CCNF	Homo sapiens	P41002	Anti Tag CoIP	22632967
Intra	RRM2	P31350	CCNF	Homo sapiens	P41002	Confocal	22632967
Intra	RRM2	P31350	RRM1	Homo sapiens	P23921	Anti Tag CoIP	22632967
Intra	RRM2	P31350	FZR1	Homo sapiens	Q9UM11	Pull Down	22632967
Intra	RRM2	P31350	FZR1	Homo sapiens	Q9UM11	Anti Tag CoIP	22632967
Intra	RRM2	P31350	FZR1	Homo sapiens	Q9UM11	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RRM2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71267	RRM2 Protein, Human (HEK293, His)	P31350-1 (M1-F389)	≥ 95%, as determined by reducing SDS-PAGE.

RRM2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82140	RRM2 Antibody (YA1885)	WB, ICC/IF, IP	Human
HY-P82140A	RRM2 Antibody (YA1885)(PBS only)	WB, ICC/IF, IP	Human

Related Diseases

Diseases	Alias
Diamond-Blackfan Anemia 20	DBA20 Rps15a-Related Diamond-Blackfan Anemia
Choriocarcinoma	Chorioepithelioma
Breast Disease	Breast Diseases
Syndromic X-Linked Intellectual Disability 94	Mrx94 Mrxs29 Syndromic X-Linked Intellectual Disability Due To Gria3 Anomalies Syndromic X-Linked Mental Retardation 29 Syndromic X-Linked Mental Retardation Wu Type
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Oral Cavity Cancer	Malignant Neoplasm Of Floor Of Mouth Oral Cavity Carcinoma Malignant Neoplasm Of Mouth
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Tongue Disease	Abnormality Of The Tongue Tongue Diseases Tongue Disorders Disorder Of Tongue Glossopathy Unspecified Condition Of The Tongue
Oral Squamous Cell Carcinoma	Mouth Squamous Cell Carcinoma Squamous Cell Carcinoma Of Mouth
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-30272	Monobenzone		99.93%	Unkown
HY-B2116	Osalmid	Inhibitor	99.91%	Unkown

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0527	Pentagalloylglucose		99.57%	Unkown
HY-P5960	PTBP1-RNA-binding inhibitor P6 TFA		98.59%	Unkown
HY-153898	rTRD01	Ligand	99.10%	Unkown
HY-153736	NSC 194308		99.86%	Unkown
HY-112358	GW8510	Inhibitor	99.04%	Unkown
HY-RS12286	RRM2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12287	RRM2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16616	Rrm2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21746	Rrm2b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23051	Rrm2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28263	Rrm2b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RRM2	VGNC	VGNC:103859
Mus musculus	RRM2	MGD	MGI:98181
Felis catus	RRM2	VGNC	VGNC:81213
Bos taurus	RRM2	VGNC	VGNC:34165
Canis familiaris	RRM2	VGNC	VGNC:45761
Rattus norvegicus	RRM2	RGD	RGD:1598310
Others	RRM2	NCBI