ZP3 - zona pellucida glycoprotein 3 Gene

Also Known as ZPC; ZP3A; ZP3B; Zp-3; OOMD3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7784

About ZP3

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:76,397,522-76,442,069 (from NCBI)

This gene has 7 transcripts (splice variants), 839 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 5.0), skin (RPKM 3.3) and 25 other tissues.

Summary

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus Furin cleavage site, and a transmembrane domain. It is hypothesized that Furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for Furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene. [provided by RefSeq, Jul 2008]

ZP3 Products (2)

mRNA Protein Name
NM_001110354.2 NP_001103824.1 zona pellucida sperm-binding protein 3 isoform 1 precursor
NM_007155.6 NP_009086.4 zona pellucida sperm-binding protein 3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables acrosin binding IPI
IPI: Inferred from physical interaction
15950651 GOA
enables carbohydrate binding IDA
IDA: Inferred from direct assay
19246320 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
26879157 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15950651 GOA
Biological Process GO Annotation Evidence References Source
involved in binding of sperm to zona pellucida IDA
IDA: Inferred from direct assay
19246320 GOA
involved in binding of sperm to zona pellucida IGI
IGI: Inferred from genetic interaction
9609824 GOA
involved in binding of sperm to zona pellucida IMP
IMP: Inferred from mutant phenotype
19004505 GOA
involved in negative regulation of binding of sperm to zona pellucida IDA
IDA: Inferred from direct assay
18667750 GOA
involved in positive regulation of acrosomal vesicle exocytosis IDA
IDA: Inferred from direct assay
19246320 GOA
involved in positive regulation of acrosomal vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
19004505 GOA
involved in positive regulation of acrosome reaction IDA
IDA: Inferred from direct assay
11751269 GOA
involved in positive regulation of humoral immune response IDA
IDA: Inferred from direct assay
19004505 GOA
Cellular Component GO Annotation Evidence References Source
located in collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
19246320 GOA
located in egg coat IDA
IDA: Inferred from direct assay
29895852 GOA
located in extracellular space IMP
IMP: Inferred from mutant phenotype
19246320 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZP3 Protein Structure

Zona_pellucida

Zona_pellucida: Zona pellucida-like domain (45 - 301)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 424 a.a.
Protein Preferred Names Protein Names

zona pellucida sperm-binding protein 3

  • ZP3A/ZP3B

ZP3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZP3 P21754 VDAC2 Homo sapiens P45880-3
Far-WB
23355646
Intra
ZP3 P21754 VDAC2 Homo sapiens P45880-3
Pull Down
23355646
Intra
ZP3 P21754 SPACA3 Homo sapiens Q8IXA5
Gal4 VP16 Complement
19945174
Intra
ZP3 P21754 UBAP2L Homo sapiens Q14157
Gal4 VP16 Complement
19945174
Intra
ZP3 P21754 ZP3 Homo sapiens P21754
X-Ray Diffraction
26879157
Intra
ZP3 P21754 PCDH17 Homo sapiens O14917
Gal4 VP16 Complement
19945174
Intra
ZP3 P21754 ENO1 Homo sapiens P06733
Far-WB
23355646
Intra
ZP3 P21754 GPX4 Homo sapiens P36969
Far-WB
23355646
Intra
ZP3 P21754 ACR Homo sapiens P10323
ELISA
15950651
Intra
ZP3 P21754 PKM Homo sapiens P14618-2
Far-WB
23355646
Intra
ZP3 P21754 MICALL1 Homo sapiens Q8N3F8
Gal4 VP16 Complement
19945174
Intra
ZP3 P21754 GAPDHS Homo sapiens O14556
Far-WB
23355646
Intra
ZP3 P21754 GSTM3 Homo sapiens P21266
Far-WB
23355646
Intra
ZP3 P21754 ZP3 Homo sapiens P21754
EM
26879157
Intra
ZP3 P21754 PCDH17 Homo sapiens O14917
Y2H
19945174
Intra
ZP3 P21754 ODF2 Homo sapiens Q5BJF6-5
Far-WB
23355646
Intra
ZP3 P21754 ZP3 Homo sapiens P21754
IR Spectrometry
26879157
Intra
ZP3 P21754 SPACA3 Homo sapiens Q8IXA5
Y2H
19945174
Intra
ZP3 P21754 P10323-PRO_0000027518 Homo sapiens P10323-PRO_0000027518
ELISA
15950651
Intra
ZP3 P21754 MICALL1 Homo sapiens Q8N3F8
Y2H
19945174
Intra
ZP3 P21754 UBAP2L Homo sapiens Q14157
Y2H
19945174
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ZP3 Proteins

Cat. No. Product Name Accession Purity
HY-P71672 ZP3 Protein, Human (HEK293, His-Myc) P21754 (Q23-V387) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Oocyte Maturation Defect 3

  • OOMD3

  • Oocyte Maturation Defect, Type 3
Female Infertility Due To Zona Pellucida Defect
Infertility
Ovarian Disease

  • Ovarian Dysfunction

  • Ovarian Diseases

  • Ovarian Disorders

  • Disorder Of Endocrine Ovary
Epilepsy, Familial Temporal Lobe, 4

  • ETL4

  • Epilepsy, Occipitotemporal Lobe, And Migraine With Aura

  • Epolm

  • Familial Temporal Lobe Epilepsy 4

  • Occipitotemporal Lobe Epilepsy And Migraine With Aura
Ovarian Dysgenesis 2

  • Premature Ovarian Failure 4

  • ODG2

  • Ovarian Dysgenesis, Hypergonadotropic, X-Linked

  • Ovarian Failure, Hypergonadotropic, Due To Ovarian Dysgenesis

  • Ovarian Failure Hypergonadotropic Due To Ovarian Dysgenesis

  • X-Linked Hypergonadotropic Ovarian Dysgenesis

  • POF4

  • Dysgenesis, Ovarian, Type 2
Cataract 1, Multiple Types

  • Cataract 1 Multiple Types

  • CTRCT1

  • Cataract 1, Multiple Types, With Or Without Microcornea

  • Czp1

  • Cae1

  • Pulverulent Zonular Cataract

  • Cataract, Duffy-Linked

  • Cataract, Zonular Pulverulent, 1

  • Duffy Linked Cataract

  • Zonular Pulverulent Cataract 1

  • Cataract Duffy-Linked

  • Cataract-Microcornea Syndrome

  • Cataract Zonular Pulverulent 1

  • Ccmc

  • Cznp

  • Czp

  • Zonular Nuclear Pulverulent Cataract

  • Cataract, Zonular Pulverulent-1

  • Zonular Pulverulent Cataract

  • Cataract, Zonular Pulverulent 1

  • Cataract Microcornea Syndrome
Premature Menopause

  • Primary Ovarian Insufficiency

  • Premature Ovarian Failure

  • Hypergonadotropic Hypogonadism

  • Premature Ovarian Insufficiency

  • Menopause - Premature

  • Menopause Praecox

  • Menopause Premature

  • Menopause, Premature

  • Female Hypergonadotropic Hypogonadism

  • Hypergonadotrophic Ovarian Failure

  • Primary Female Hypogonadism

  • Pof - [Premature Ovarian Failure]

  • Ovarian Failure

  • Ovarian Secretion Suppression

  • Ovary Hyposecretion

  • Ovary Secretion Deficiency

  • Premature Menopause Nos
Gaucher Disease, Type Iiic

  • Gaucher Disease-Ophthalmoplegia-Cardiovascular Calcification Syndrome

  • Gaucher-Like Disease

  • GD3C

  • Gaucher'S Disease Type Iiic

  • Cardiovascular Gaucher Disease

  • Gaucher Disease Type 3c

  • Gaucher Disease 3c

  • Pseudo-Gaucher Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16188 ZP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17941 Zp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24412 Zp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ZP3 VGNC VGNC:108456
Felis catus ZP3 VGNC VGNC:107838
Mus musculus ZP3 MGD MGI:99215
Rattus norvegicus ZP3 RGD RGD:620606
Others ZP3 NCBI