GSTM3 - glutathione S-transferase mu 3 Gene

Also Known as GST5; GSTB; GTM3; GSTM3-3; hGSTM3-3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2947

About GSTM3

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,733,937-109,741,038 (from NCBI)

This gene has 5 transcripts (splice variants), 258 orthologues, 11 paralogues and is associated with 1 phenotype. Broad expression in testis (RPKM 82.2), kidney (RPKM 34.8) and 16 other tissues.

Summary

Cytosolic and membrane-bound forms of Glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a Glutathione S-transferase that belongs to the mu class. The mu class of Enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of Enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

GSTM3 Products (1)

mRNA	Protein	Name
NM_000849.5	NP_000840.2	glutathione S-transferase Mu 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	8373352	GOA
enables glutathione binding	IDA IDA: Inferred from direct assay	8373352	GOA
enables glutathione transferase activity	IDA IDA: Inferred from direct assay	8373352	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23355646	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	9545290	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	8373352	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular detoxification of nitrogen compound	IDA IDA: Inferred from direct assay	8373352	GOA
involved in glutathione metabolic process	IDA IDA: Inferred from direct assay	8373352	GOA
involved in nitrobenzene metabolic process	IDA IDA: Inferred from direct assay	8373352	GOA
involved in response to estrogen	IEP IEP: Inferred from expression pattern	10037815	GOA
involved in xenobiotic catabolic process	IDA IDA: Inferred from direct assay	8373352	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	8373352	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GSTM3 Protein Structure

GST_N

GST_C

0
100
200
225 a.a.

Protein Preferred Names	Protein Names
glutathione S-transferase Mu 3	GST class-mu 3

GSTM3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GSTM3	P21266	CLVS2	Homo sapiens	Q5SYC1	Validated Y2H	32296183
Intra	GSTM3	P21266	CLVS2	Homo sapiens	Q5SYC1	Y2H Prey Pooling	32296183
Intra	GSTM3	P21266	CLVS2	Homo sapiens	Q5SYC1	Y2H Array	32296183
Intra	GSTM3	P21266	GSTM3	Homo sapiens	P21266	Y2H Array	19060904
Intra	GSTM3	P21266	GSTM3	Homo sapiens	P21266	Y2H Pooling	16189514
Intra	GSTM3	P21266	GSTM5	Homo sapiens	P46439	Y2H Prey Pooling	32296183
Intra	GSTM3	P21266	GSTM3	Homo sapiens	P21266	Validated Y2H	32296183
Intra	GSTM3	P21266	GSTM4	Homo sapiens	Q03013	Y2H Prey Pooling	32296183
Intra	GSTM3	P21266	GSTM5	Homo sapiens	P46439	Validated Y2H	32296183
Intra	GSTM3	P21266	GSTM3	Homo sapiens	P21266	Y2H Array	32296183
Intra	GSTM3	P21266	GSTM5	Homo sapiens	P46439	Y2H Array	32296183
Intra	GSTM3	P21266	GSTM5	Homo sapiens	P46439	MAPPIT	32296183
Intra	GSTM3	P21266	GSTM3	Homo sapiens	P21266	Y2H Prey Pooling	32296183
Intra	GSTM3	P21266	GSTM3	Homo sapiens	P21266	Y2H	21516116
Intra	GSTM3	P21266	GSTM3	Homo sapiens	P21266	Y2H Array	31515488
Intra	GSTM3	P21266	GSTM5	Homo sapiens	P46439	Complementation	32296183
Intra	GSTM3	P21266	GSTM3	Homo sapiens	P21266	Y2H Pooling	19060904
Intra	GSTM3	P21266	GSTM5	Homo sapiens	P46439	Y2H Array	31515488
Intra	GSTM3	P21266	GSTM4	Homo sapiens	Q03013	Validated Y2H	32296183
Intra	GSTM3	P21266	GSTM4	Homo sapiens	Q03013	Y2H Array	32296183
Intra	GSTM3	P21266	GSTM4	Homo sapiens	Q03013	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Larynx Cancer	Laryngeal Carcinoma Laryngeal Cancer Laryngeal Neoplasm Carcinoma Of Larynx Malignant Neoplasm Of Larynx Cancer Of Larynx Laryngeal Neoplasms Cancer, Laryngeal
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Pharynx Cancer	Pharyngeal Cancer Pharyngeal Neoplasms Pharyngeal Neoplasm Pharynx Neoplasm Malignant Neoplasm Of Pharynx Pharyngeal Carcinoma
Laryngeal Squamous Cell Carcinoma	Epidermoid Carcinoma Of The Larynx Squamous Cell Carcinoma Of Larynx Squamous Cell Carcinoma Of The Larynx Squamous Cell Carcinoma Of Head And Neck
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Open-Angle Glaucoma	Glaucoma Simplex Pigmentary Glaucoma Wide-Angle Glaucoma Glaucoma, Open-Angle Open Angle Glaucoma Glaucoma Open-Angle Chronic Simple Glaucoma Coag - [Chronic Open-Angle Glaucoma] Csg - [Chronic Simple Glaucoma] Poag - [Primary Open-Angle Glaucoma] Oag - [Open-Angle Glaucoma] Chronic Glaucoma Chronic Open Angle Glaucoma Simple Glaucoma Chronic Noncongestive Glaucoma Ltg - [Low Tension Glaucoma] Noncongestive Glaucoma Nonobstructive Glaucoma Normal Pressure Glaucoma Primary Low Tension Glaucoma Low-Tension Glaucoma Residual Stage Low Tension Glaucoma Open Cleft Glaucoma
Brugada Syndrome	Sudden Unexpected Nocturnal Death Syndrome Sudden Unexplained Nocturnal Death Syndrome Bangungut Brugada Type Idiopathic Ventricular Fibrillation Pokkuri Death Syndrome Sunds Idiopathic Ventricular Fibrillation, Brugada Type Sudden Unexplained Death Dream Disease Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome Sudden Unexplained Death Syndrome Suds Sunds - [Sudden Unexplained Nocturnal Death Syndrome]
Lip And Oral Cavity Cancer	Oral Cancer Lip And Oral Cavity Carcinoma Malignant Neoplasm Of Mouth
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-146577	Keap1-Nrf2-IN-7	Inhibitor	99.82%	Unkown
HY-146578	Keap1-Nrf2-IN-8	Inhibitor	/	Unkown
HY-149245	Keap1-Nrf2-IN-15	Inhibitor	/	Unkown
HY-RS05881	GSTM3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-162096	Keap1-Nrf2-IN-17	Inhibitor	/	Unkown
HY-RS17764	Gstm3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24231	Gstm3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27466	Gstm5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GSTM3	MGD	MGI:1309466
Rattus norvegicus	GSTM3	RGD	RGD:61964
Canis familiaris	GSTM3	VGNC	VGNC:54033
Felis catus	GSTM3	VGNC	VGNC:108363
Bos taurus	GSTM3	VGNC	VGNC:29686
Macaca mulatta	GSTM3	VGNC	VGNC:73303
Others	GSTM3	NCBI