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Cat. No.: HY-179681

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A2A/A3 agonist-1

A2A/A3 agonist-1 is a dual A_2A/A₃ adenosine receptor agonist. A2A/A3 agonist-1 has a K_i value of 2.9 nM and an EC₅₀ of 0.51 nM for hA_2AAR. A2A/A3 agonist-1 has a K_i of 0.8 nM and an EC₅₀ < 0.10 nM for hA₃AR. A2A/A3 agonist-1 possesses anti-inflammatory activity and can be used for the research of inflammatory diseases.

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화학식: C₁₈H₂₄N₆O₃S
분자량:404.49

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

A2A/A3 agonist-1 Chemical Structure

사이즈

가격

재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Adenosine Receptor Isoforms :

In Vitro

A2A/A3 agonist-1 (10-50 nM; 24 h) exhibits potent inhibitory effects on IL-12/IL-23p40 and IL-6 in LPS (HY-D1056)-stimulated bone marrow-derived dendritic cells (BMDCs)¹.
A2A/A3 agonist-1 (1 μM; 0-60 min) shows favorable metabolic stability in human liver microsomes and plasma with no meaningful hERG inhibition¹.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA Assay^[1]

Cell Line:

LPS treated BMDCs
Concentration:

10,50 nM
Incubation Time:

24h
Result:

Inhibited the production of IL-12/IL-23p40 and IL-6.

Chemical Information

분자량 404.49
화학식 C₁₈H₂₄N₆O₃S
SMILES

O[C@H]1[C@@H](O)[C@H](N(C=N2)C3=C2C(N)=NC(C#CCCCC)=N3)S[C@@H]1C(NCC)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kim SW, et al. Structure-activity relationship analysis of 5'-substituted C2-hexynyl-4'-thioadenosine analogs as dual A2A/A3 adenosine receptor agonists with tunable selectivity and anti-inflammatory activity. Eur J Med Chem. 2026 Jan 15;302(Pt 3):118386. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

A2A/A3 agonist-1

All Adenosine Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

A2A/A3 agonist-1 Related Classifications

HY-179681 Related Classifications