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Cat. No.: HY-184796

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AChE-IN-119

AChE-IN-119 is a selective acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 0.0641 μM and a K_i of 0.01648 μM. AChE-IN-119 exerts antioxidant effects by scavenging DPPH free radicals. AChE-IN-119 exhibits mixed-type inhibition and interacts with both the catalytic active site and the peripheral anionic site of acetylcholinesterase. AChE-IN-119 can be used for the research of Alzheimer's disease.

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화학식: C₂₀H₁₃ClN₄O₂S
분자량:408.86

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

AChE-IN-119 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

AChE

0.01648 μM (Ki)

AChE

0.0641 μM (IC₅₀)

All Cholinesterase (ChE) Isoforms :

AChE
BChE

In Vitro

AChE-IN-119 (compound 4) potently inhibits purified acetylcholinesterase (AChE) via a mixed-type inhibition mechanism, with an IC₅₀ of 0.0641 μM. It exhibits 108-fold higher selectivity for AChE over butyrylcholinesterase (BChE), and its K_i value against AChE is 0.01648 μM^[1].
AChE-IN-119 exerts antioxidant effects by scavenging DPPH free radicals, with an IC₅₀ of 10.01 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 408.86
화학식 C₂₀H₁₃ClN₄O₂S
SMILES

CN(C1=CC=C(Cl)C=C1/C2=N/NC3=NC=C(C4=CC(C=CC=C5)=C5O4)S3)C2=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Lotfy EM, et al. Microwave-assisted green synthesis and biological evaluation of a novel isatin-thiazole-benzofuran hybrid with dual acetylcholinesterase inhibitory and antioxidant activities. Bioorganic chemistry. 2026 Jun 25;180:110163. [Content Brief]

Calculators

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Molecular Weight Molecular Weight

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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AChE-IN-119

All Cholinesterase (ChE) Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

AChE-IN-119 Related Classifications

HY-184796 Related Classifications