AHL-7160
AHL-7160 is a covalent DGKα inhibitor that possesses dual functions of enzyme activity inhibition (IC₅₀ ≈ 12 nM) and molecular gel-mediated degradation. AHL-7160 can rapidly recruit endogenous DGKα to the cell membrane (EC₅₀ = 39 nM), and this effect has isozyme selectivity. AHL-7160 can stereospecifically block phosphatidylcholine acid (PA) production mediated by DGKα (IC₅₀ = 340 nM). AHL-7160 enhances T cell activation and promotes anti-tumor immune responses. AHL-7160 can be used for research on immunotherapy.
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- 화학식: C28H30N8O3S
- 분자량:558.65
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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ERK1 |
ERK2 |
IL-2 |
IL-5 |
IL-10 |
IL-17A |
Chemical Information
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분자량 558.65
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화학식 C28H30N8O3S
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SMILES
CN(C1=CC=C(C#N)N=C1C(N2C[C@@H](C)N(CC3=CC=C(S(N4C=NC(C5CC5)=N4)(=O)=O)C=C3)C[C@@H]2C)=C6)C6=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AHL-7160 Related Classifications
HY-180898 Related Classifications
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