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Cat. No.: HY-182399

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BC-DXI-495

BC-DXI-495 is a AIMP2-DX2 inhibitor. BC-DXI-495 disrupts the interaction of HSP70 and destabilizes DX2. BC-DXI-495 induces DX2 degradation via Siah1-mediated ubiquitination. BC-DXI-495 exerts tumor suppressive activity in cancer cells. BC-DXI-495 serves as a chemical probe to elucidate the mechanism of action of arylsulfonamide-based DX2 inhibitors. BC-DXI-495 can be used in lung cancer research.

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CAS No.: 2421117-94-2
화학식: C₂₈H₃₀N₄O₄S
분자량:518.63

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

BC-DXI-495 Chemical Structure

CAS No.: 2421117-94-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
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Bioz

Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
A549	EC₅₀	14.2 μM Compound: 2; BC-DXI-495	Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay	[PMID: 32315177]

In Vitro

BC-DXI-495 (Compound 2) inhibits the level of NanoLuciferase-tagged DX2 by 67.10%^[1].
BC-DXI-495 inhibits the degradation of DX2 protein, with an IC₅₀ value of 4.20 μM^[1].
BC-DXI-495 (72 h) inhibits the viability of A549 lung cancer cells with an EC₅₀ of 14.2 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2421117-94-2
분자량 518.63
화학식 C₂₈H₃₀N₄O₄S
SMILES

O=S(N[C@H](C(NC1=CC=C(N2CCOCC2)C=C1)=O)CC3=CNC4=CC=CC=C34)(C5=CC=C(C=C5)C)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Sivaraman A, et al. Synthesis and Structure-Activity Relationships of Arylsulfonamides as AIMP2-DX2 Inhibitors for the Development of a Novel Anticancer Therapy. J Med Chem. 2020;63(10):5139-5158. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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