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CAY10701

CAY10701 (Compound 20) is a 7-deazahypoxanthine analogue with anticancer activity.

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CAS No.: 1616967-52-2
화학식: C₂₄H₁₉N₃O₂
분자량:381.43

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

CAY10701 Chemical Structure

CAS No.: 1616967-52-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Bioz

Biological Activity

제품 설명

CAY10701 (Compound 20) is a 7-deazahypoxanthine analogue with anticancer activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	GI₅₀	0.022 μM Compound: 1	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 38865195]
HeLa	GI₅₀	0.22 μM Compound: 7	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 26641132]
MCF7	GI₅₀	0.038 μM Compound: 7	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 26641132]
RKO	GI₅₀	0.009 μM Compound: 7	Antiproliferative activity against human RKO cells after 72 hrs by SRB assay Antiproliferative activity against human RKO cells after 72 hrs by SRB assay	[PMID: 26641132]
SK-CO-1	GI₅₀	0.17 μM Compound: 7	Antiproliferative activity against human SKCO1 cells after 72 hrs by SRB assay Antiproliferative activity against human SKCO1 cells after 72 hrs by SRB assay	[PMID: 26641132]
SW48	GI₅₀	0.012 μM Compound: 7	Antiproliferative activity against human SW48 cells after 72 hrs by SRB assay Antiproliferative activity against human SW48 cells after 72 hrs by SRB assay	[PMID: 26641132]
SW-620	GI₅₀	0.011 μM Compound: 7	Antiproliferative activity against human SW620 cells after 72 hrs by SRB assay Antiproliferative activity against human SW620 cells after 72 hrs by SRB assay	[PMID: 26641132]
WI-38	GI₅₀	25.4 μM Compound: 7	Antiproliferative activity against human WI38 cells after 72 hrs by SRB assay Antiproliferative activity against human WI38 cells after 72 hrs by SRB assay	[PMID: 26641132]

In Vitro

CAY10701 (Compound 20) (48 h) inhibits cell proliferation in HeLa and MCF cells with IC50 values of 12.4 μM and 58.8 μM, respectively ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1616967-52-2
분자량 381.43
화학식 C₂₄H₁₉N₃O₂
SMILES

O=C1C2=C(NC(CCCC#C)=N1)NC(C(C3=CC=CC=C3)=O)=C2C4=CC=CC=C4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. van der Westhuyzen, et al. "Improved Rigidin-Inspired Antiproliferative Agents with Modifications on the 7-Deazahypoxanthine C7/C8 Ring Systems." Journal of Medicinal Chemistry (2024). [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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