Cat. No.: HY-138429

COQ7-IN-2

1 Cited Publications

고객리뷰

Based on 1 publication(s) in Google Scholar

COQ7-IN-2 (compound 12) is an inhibitor of COQ7, witn IC₅₀ values of 7.3 μM and 15.4 μM for DMQ₁₀ and UQ₁₀ accumulation, respectively.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 99.74%
CAS No.: 2579696-76-5
화학식: C₁₅H₁₃N₃O
분자량:251.28

보관:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

COQ7-IN-2 Chemical Structure

CAS No.: 2579696-76-5

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Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
Publications (1)
용액&용해도
- In Vitro
- In Vivo
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

COQ7-IN-2 (compound 12) is an inhibitor of COQ7, witn IC₅₀ values of 7.3 μM and 15.4 μM for DMQ₁₀ and UQ₁₀ accumulation, respectively^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
C3A	GI₅₀	18.5 μM Compound: 12	Growth inhibition of human C3A cells assessed as growth inhibition after 3 days by cell-titer-Glo assay Growth inhibition of human C3A cells assessed as growth inhibition after 3 days by cell-titer-Glo assay	[PMID: 31753803]
C3A	GI₅₀	20.2 μM Compound: 12	Growth inhibition of human C3A cells after 3 days in presence of 10 mM 2-DG by cell-titer-Glo assay Growth inhibition of human C3A cells after 3 days in presence of 10 mM 2-DG by cell-titer-Glo assay	[PMID: 31753803]
HeLa	GI₅₀	>12 μM Compound: 12	Growth inhibition of human HeLa cells assessed as growth inhibition after 3 days by cell-titer-Glo assay Growth inhibition of human HeLa cells assessed as growth inhibition after 3 days by cell-titer-Glo assay	[PMID: 31753803]
PANC-1	GI₅₀	>12 μM Compound: 12	Growth inhibition of human PANC1 cells after 3 days by cell-titer-Glo assay Growth inhibition of human PANC1 cells after 3 days by cell-titer-Glo assay	[PMID: 31753803]
PC-3	GI₅₀	>12 μM Compound: 12	Cytotoxicity against human PC3 cells assessed as growth inhibition after 3 days by cell-titer-Glo assay Cytotoxicity against human PC3 cells assessed as growth inhibition after 3 days by cell-titer-Glo assay	[PMID: 31753803]

In Vitro

COQ7-IN-2 (compound 12) has less growth inhibition against human normal culture cells^[1].
The substantial DMQ₁₀ accumulation occurred in both PANC-1 cells (8.7% by COQ7-IN-2 (compound 12)) and PC3 cells (14.0% by COQ7-IN-2 (compound 12))^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2579696-76-5
Appearance Solid
분자량 251.28
화학식 C₁₅H₁₃N₃O
Color White to off-white
SMILES

OC1=CC(C2=CC=CC=C2)=NN1C3=NC=C(C)C=C3
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Chem Biol Interact

4-Hydroxybenzoic acid restrains Nlrp3 inflammasome priming and activation via disrupting PU.1 DNA binding activity and direct antioxidation. [Abstract]

2024 Dec 1:404:111262. PMID: 39389441

용액&용해도

In Vitro:

DMSO : 25 mg/mL (99.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.9796 mL

19.8981 mL

39.7962 mL

5 mM

0.7959 mL

3.9796 mL

7.9592 mL

10 mM

0.3980 mL

1.9898 mL

3.9796 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (9.95 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Keiko Tsuganezawa, et al. Identification of small molecule inhibitors of human COQ7. Bioorg Med Chem. 2020 Jan 1;28(1):115182. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.9796 mL	19.8981 mL	39.7962 mL	99.4906 mL
	5 mM	0.7959 mL	3.9796 mL	7.9592 mL	19.8981 mL
	10 mM	0.3980 mL	1.9898 mL	3.9796 mL	9.9491 mL
	15 mM	0.2653 mL	1.3265 mL	2.6531 mL	6.6327 mL
	20 mM	0.1990 mL	0.9949 mL	1.9898 mL	4.9745 mL
	25 mM	0.1592 mL	0.7959 mL	1.5918 mL	3.9796 mL
	30 mM	0.1327 mL	0.6633 mL	1.3265 mL	3.3164 mL
	40 mM	0.0995 mL	0.4975 mL	0.9949 mL	2.4873 mL
	50 mM	0.0796 mL	0.3980 mL	0.7959 mL	1.9898 mL
	60 mM	0.0663 mL	0.3316 mL	0.6633 mL	1.6582 mL
	80 mM	0.0497 mL	0.2487 mL	0.4975 mL	1.2436 mL

Keywords

COQ7-IN-2

1 Cited Publications

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COQ7-IN-2

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Publications Citing Use of MedChemExpress (MCE) COQ7-IN-2

Biological Activity

Chemical Information

Publications (1)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

COQ7-IN-2

Reprogramming Compound Library

Glutamine Metabolism Compound Library

Anti-Cancer Metabolism Compound Library

Anti-Parkinson's Disease Compound Library

Neurodegenerative Disease-related Compound Library

Mitochondria-Targeted Compound Library

Glucose Metabolism Compound Library

Cuproptosis Compound Library

Cancer Stem Cells Compound Library

Heterocyclic Compound Library

Mitochondrial Protection Compound Library

Metabolic Enzyme Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Metabolism/Protease Compound Library

Stem Cell Signaling Compound Library

Anti-Aging Compound Library

Publications Citing Use of MedChemExpress (MCE) COQ7-IN-2

Biological Activity

Chemical Information

Publications (1)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

COQ7-IN-2 Related Classifications

HY-138429 Related Classifications