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Cat. No.: HY-P11752

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Cyclo(KLARLLT)

Cyclo (KLARLLT) is an EGFR ligand with a K_d value of 1.16 μM. Cyclo (KLARLLT) binds to domain I of EGFR and interacts with both the open and closed conformations of EGFR. Cyclo (KLARLLT) is a modified variant of LARLLT (HY-P11078). Cyclo (KLARLLT) can be used in the research of colorectal cancer.

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화학식: C₃₇H₆₉N₁₁O₈
분자량:796.01

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

맞춤형 펩타이드 합성

Cyclo(KLARLLT) Chemical Structure

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All EGFR Isoforms :

In Vitro

Cyclo (KLARLLT) (0-200 μM) binds to the purified extracellular domain of EGFR, with a K_D value of 1.16 μM^[1].
Cyclo (KLARLLT) binds to domain I of EGFR (including both open and closed conformations), and its low-energy structure is stabilized by hydrogen bonds and hydrophobic interactions^[1].
Cyclo (KLARLLT) (2 mg/mL; 0-48 h at 37°C) exhibits significantly improved stability in human serum compared with its linear analog KLARLLT; nearly 60% of the peptide remains intact after incubation at 37°C for 48 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 796.01
화학식 C₃₇H₆₉N₁₁O₈
Sequence

Cyclo(Lys-Leu-Ala-Arg-Leu-Leu-Thr)
Sequence Shortening

Cyclo(KLARLLT)
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Williams TM, et al. Peptide ligands for targeting the extracellular domain of EGFR: Comparison between linear and cyclic peptides. Chem Biol Drug Des. 2018;91(2):605-619. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration Concentration

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Molecular Weight Molecular Weight

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Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

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Cyclo(KLARLLT)

All EGFR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Cyclo(KLARLLT) Related Classifications

HY-P11752 Related Classifications