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Cat. No.: HY-119114

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E-2508 free base

E-2508 free base is an orally active and highly selective corticotropin-releasing factor type 1 receptor (CRF1) antagonist with anxiolytic effects (K_i=11 nM). E-2508 free base blocks CRF-induced cAMP accumulation via CRF1 receptor inhibition. E-2508 free base is promising for research of stress-related psychiatric disorders, such as anxiety and depression.

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CAS No.: 685885-75-0
화학식: C₂₉H₃₉N₃O₄
분자량:493.64

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

E-2508 free base Chemical Structure

CAS No.: 685885-75-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All CRFR Isoforms :

CRFR1
CRFR2

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	23 nM Compound: 24r	Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-stimulated cAMP accumulation after 30 mins by fluorescence analysis Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-stimulated cAMP accumulation after 30 mins by fluorescence analysis	[PMID: 22587443]
HEK293	IC₅₀	50 nM Compound: 24r	Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counter Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counter	[PMID: 22587443]

Chemical Information

CAS No. 685885-75-0
분자량 493.64
화학식 C₂₉H₃₉N₃O₄
SMILES

CCC1=NN2C(C3=C(C=C(C=C3OC)COC)OC)=CC=CC2=C1N(CC4CCOCC4)CC5CC5
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Takahashi Y, et al. Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: potent and orally active antagonists of corticotropin-releasing factor 1 receptor. J Med Chem. 2012 Jun 14;55(11):5255-69. [Content Brief]

Calculators

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Concentration Concentration

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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E-2508 free base

All CRFR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

E-2508 free base Related Classifications

HY-119114 Related Classifications