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Cat. No.: HY-161269

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EGFR-IN-101

EGFR-IN-101 (I-10) is a 2-phenylamino pyrimidine derivative. EGFR-IN-101 is a EGFR inhibitor. The IC₅₀ values for EGFR^{L858R/T790M/C797S} and Ba/F3-EGFR^{L858R/T790M/C797S} are 33.26 and 106.4 nM, respectively. EGFR-IN-101 can be used IN the study of non-small cell lung cancer (NSCLC).

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CAS No.: 2982583-44-6
화학식: C₃₅H₄₇N₉O₂
분자량:625.81

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

EGFR-IN-101 Chemical Structure

CAS No.: 2982583-44-6

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

EGFR^[1]

All EGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	106.4 nM Compound: I-10	Antiproliferative activity against mouse BAF3 cells harboring EGFR L858R/T790M/C797S mutant Antiproliferative activity against mouse BAF3 cells harboring EGFR L858R/T790M/C797S mutant	[PMID: 38331226]

Chemical Information

CAS No. 2982583-44-6
분자량 625.81
화학식 C₃₅H₄₇N₉O₂
SMILES

CN1CCN(C2CCN(C3=CC(OC)=C(NC4=NC=CC(N5C=C(CN[C@@H](C)CO)C(C6=CC=CC=C6)=N5)=N4)C=C3C)CC2)CC1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tang C, et al. Design, synthesis and biological evaluation of 2-phenylaminopyrimidine derivatives as EGFR inhibitors. Bioorg Med Chem Lett. 2024 Feb 6;101:129648. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

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EGFR-IN-101

All EGFR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

EGFR-IN-101 Related Classifications

HY-161269 Related Classifications