EGFR-IN-36
EGFR-IN-36 is a potent EGFR inhibitor with IC50s of 19.09 nM, 120.01 nM, 2.35 nM for EGFR (WT), HER2 (WT), HER2 (A775_G776insYVMA), respectively. EGFR-IN-36 has potential for wild and/or mutant EGFR and/or HER2 kinase mediated tumors research.
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- CAS No.: 2711105-54-1
- 화학식: C26H25ClN6O2
- 분자량:488.97
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All EGFR Isoforms
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Biological Activity
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EGFR (WT) 19.09 nM (IC50) |
HER2(WT) 120.01 nM (IC50) |
HER2 (A775_G776insYVMA) 2.35 nM (IC50) |
EGFR-IN-36 (compound 8) inhibits A431 cell (IC50=223.6 nM),A549 cell (IC50=7644.42 nM), H1975 cell (IC50=20.68 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2711105-54-1
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분자량 488.97
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화학식 C26H25ClN6O2
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SMILES
C=CC(N1CC(C2=CC(C3=CC=C(OCC4=NC=CC=C4)C(Cl)=C3)=C5C(N)=NC=NN52)CCC1)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR-IN-36 Related Classifications
HY-144053 Related Classifications
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