Cyp11b1 - cytochrome P450, family 11, subfamily b, polypeptide 1 Gene

Also Known as FHI; CPN1; Cyp11b; Cyp11b-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 110115

Summary

Enables corticosterone 18-monooxygenase activity. Acts upstream of or within glucocorticoid biosynthetic process. Located in mitochondrion. Is expressed in adrenal gland; gland; lung; and testis. Used to study congenital adrenal hyperplasia. Human ortholog(s) of this gene implicated in several diseases, including congenital adrenal hyperplasia; corticosterone methyloxidase deficiency 1; diabetes mellitus (multiple); hypertension (multiple); and primary hyperaldosteronism (multiple). Orthologous to human CYP11B1 (Cytochrome P450 family 11 subfamily B member 1) and CYP11B2 (Cytochrome P450 family 11 subfamily B member 2). [provided by Alliance of Genome Resources, Apr 2022]

Cyp11b1 Products (1)

mRNA Protein Name
NM_001033229.3 NP_001028401.2 cytochrome P450, family 11, subfamily b, polypeptide 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables corticosterone 18-monooxygenase activity IDA
IDA: Inferred from direct assay
1686470 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within glucocorticoid biosynthetic process IDA
IDA: Inferred from direct assay
1686470 MGI
acts upstream of or within glucocorticoid biosynthetic process IMP
IMP: Inferred from mutant phenotype
10224232 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
10224232 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytochrome P450, family 11, subfamily b, polypeptide 1

  • steroid-11-beta-hydroxylase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. 상품명 효과
Purity Rare Diseases
HY-16276 Osilodrostat Inhibitor 99.82% Yes
HY-16276A Osilodrostat phosphate Inhibitor 98.83% Yes

Clinical Phase

Bioactive Molecules (2)
Cat. No. 상품명 효과
Purity Phase
HY-B0105B Levoketoconazole Inhibitor 99.82% Phase 3
HY-113986 Dexfadrostat Inhibitor 98.75% Phase 2

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-135794 11-Ketodihydrotestosterone Agonist 99.87% Unkown
HY-163689 Vicadrostat Inhibitor 98.67% Unkown
HY-101217 BI 689648 Inhibitor 99.20% Unkown
HY-135281 CYP11B2-IN-1 Inhibitor 99.83% Unkown
HY-113986C Dexfadrostat hydrochloride Inhibitor / Unkown
HY-122744 CYP11B1-IN-1 Inhibitor / Unkown
HY-151140 CYP11B1-IN-2 Inhibitor / Unkown
HY-176480 CYP11B2-IN-3 Inhibitor / Unkown
HY-RS03435 CYP11B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-116666 Etomidate acid / Unkown
HY-163751 STING-IN-9 Inhibitor / Unkown
HY-RS17315 Cyp11b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23770 Cyp11b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cyp11b1 NCBI NCBI:1584