CD59 - CD59 molecule (CD59 blood group) Gene
Also Known as 1F5; EJ16; EJ30; EL32; G344; MIN1; MIN2; MIN3; MIRL; HRF20; MACIF; MEM43; MIC11; MSK21; 16.3A5; HRF-20; MAC-IP; p18-20
Species: Homo sapiens
About CD59
This gene has 16 transcripts (splice variants), 109 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in gall bladder (RPKM 62.1), lung (RPKM 52.8) and 25 other tissues.
Summary
This gene encodes a cell surface glycoprotein that regulates complement-mediated Cell Lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
CD59 Products (8)
| mRNA | Protein | Name |
|---|---|---|
| NM_000611.6 | NP_000602.1 | CD59 glycoprotein preproprotein |
| NM_001127223.1 | NP_001120695.1 | CD59 glycoprotein preproprotein |
| NM_001127225.2 | NP_001120697.1 | CD59 glycoprotein preproprotein |
| NM_001127226.2 | NP_001120698.1 | CD59 glycoprotein preproprotein |
| NM_001127227.2 | NP_001120699.1 | CD59 glycoprotein preproprotein |
| NM_203329.3 | NP_976074.1 | CD59 glycoprotein preproprotein |
| NM_203330.2 | NP_976075.1 | CD59 glycoprotein preproprotein |
| NM_203331.3 | NP_976076.1 | CD59 glycoprotein preproprotein |
CD59 Protein Structure
UPAR_LY6: u-PAR/Ly-6 domain (28 - 95)
- 0
- 100
- 128 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
CD59 glycoprotein |
|
CD59 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
CD59 | P13987 | FAM209A | Homo sapiens | Q5JX71 | 32296183 | |
|
Intra
|
CD59 | P13987 | FAM209A | Homo sapiens | Q5JX71 | 32296183 | |
|
Intra
|
CD59 | P13987 | FAM209A | Homo sapiens | Q5JX71 | 32296183 | |
|
Intra
|
CD59 | P13987 | HTT | Homo sapiens | P42858 | 32814053 | |
|
Intra
|
CD59 | P13987 | HTT | Homo sapiens | P42858 | 32814053 | |
|
Intra
|
CD59 | P13987 | HTT | Homo sapiens | P42858 | 32814053 | |
|
Intra
|
CD59 | P13987 | TMED2 | Homo sapiens | Q15363 | 20427317 | |
|
Cross
|
CD59 | P13987 | TMED10 | Mesocricetus auratus | O35587 | 20427317 | |
|
Cross
|
CD59 | P13987 | TMED10 | Mesocricetus auratus | O35587 | 20427317 | |
|
Cross
|
CD59 | P13987 | TMED10 | Mesocricetus auratus | O35587 | 20427317 | |
|
Cross
|
CD59 | P13987 | C | Hepatitis B virus | Q778I9 | 24036449 | |
|
Cross
|
CD59 | P13987 | C | Hepatitis B virus | Q778I9 | 24036449 |
Recombinant CD59 Proteins
| Cat. No. | 상품명 | Accession | Purity |
|---|---|---|---|
| HY-P71724 | CD59 Protein, Human (P.pastoris, His) | P13987-1 (L26-N102) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P72719 | CD59 Protein, Human (HEK293, His) | P13987-1 (L26-N102) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P78906 | CD59 Protein, Human (Biotinylated, HEK293, His-Avi) | P13987-1 (L26-N102) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P700683 | CD59 Protein, Human (HEK293, hFc) | P13987-1 (L26-N102) | ≥ 95%, as determined by reducing SDS-PAGE. |
CD59 Antibodies
| Cat. No. | 상품명 | 신청 | Reactivity |
|---|---|---|---|
| HY-P83506 | CD59 Antibody (YA3251) | WB, ICC/IF, FC, IP | Human |
| HY-P85000 | CD59 Antibody (YA4692) | ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Hemolytic Anemia, Cd59-Mediated, With Or Without Immune-Mediated Polyneuropathy |
|
|
| Hemoglobinuria |
|
|
| Paroxysmal Nocturnal Hemoglobinuria |
|
|
| Hemolytic Anemia |
|
|
| Aplastic Anemia |
|
|
| Anemia, Autoimmune Hemolytic |
|
|
| Polyneuropathy |
|
|
| Budd-Chiari Syndrome |
|
|
| Lymphopenia |
|
|
| Monieziasis |
|
|
| Congenital Dyserythropoietic Anemia |
|
|
| Neuromyelitis Optica |
|
|
| Burkitt Lymphoma |
|
|
| Glomerulonephritis |
|
|
| Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 2 |
|
|
| Pick Disease Of Brain |
|
|
| Membranous Nephropathy |
|
|
| Myelodysplastic Syndrome |
|
|
| Complement Component 3 Deficiency |
|
|
| Developmental And Epileptic Encephalopathy 38 |
|
|
| Complement Component 5 Deficiency |
|
|
| Beta-Thalassemia |
|
|
| Hemolytic Uremic Syndrome, Atypical 1 |
|
|
| Waldenstroem'S Macroglobulinemia |
|
|
| Vulvar Angiokeratoma |
|
|
| Systemic Lupus Erythematosus |
|
|
| Malaria |
|
|
| Macular Degeneration, Age-Related, 1 |
|
|
| Deficiency Anemia |
|
|
| Colorectal Cancer |
|
|
| Breast Rhabdomyosarcoma |
|
|
| Myocardial Infarction |
|
|
| Meningovascular Neurosyphilis |
|
|
| Membranoproliferative Glomerulonephritis |
|
|
| Ovarian Cancer |
|
|
| Prostate Cancer |
|
|
| Melanoma, Uveal |
|
|
| Lymphoma, Non-Hodgkin, Familial |
|
|
| Leukemia, Chronic Lymphocytic |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | CD59 | VGNC | VGNC:56087 |
| Bos taurus | CD59 | VGNC | VGNC:54861 |
| Rattus norvegicus | CD59 | RGD | RGD:2311 |
| Others | CD59 | NCBI |