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Cat. No.: HY-180921

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GS-1291269

GS-1291269 is a potent and neutral ketohexokinase (KHK) inhibitor, with IC₅₀s of 0.38 and 2.1 nM against KHK-C and KHK-A, respectively. GS-1291269 demonstrates liver and kidney fructose-1-phosphate (F1P) reduction in a fructose challenge model in rats. GS-1291269 can be used for kidney disease and metabolic-dysfunction-associated steatotic liver disease (MASLD) research.

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CAS No.: 2845278-33-1
화학식: C₂₀H₁₉F₅N₄O₂S
분자량:474.45

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

GS-1291269 Chemical Structure

CAS No.: 2845278-33-1

사이즈

가격

재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

17β-HSD2

2.1 nM (IC₅₀)

17β-HSD5

0.38 nM (IC₅₀)

All Ketohexokinase Isoforms :

KHK-A
KHK-C

Chemical Information

CAS No. 2845278-33-1
분자량 474.45
화학식 C₂₀H₁₉F₅N₄O₂S
SMILES

FC1(F)C2=NC(N3[C@@H](C(F)(F)F)CC3)=NC(C4=CC=C(C5(CS(C5)(=O)=O)N)C=C4)=C2CC1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kasun ZA, et al. The Discovery of GS-1291269: A Neutral Ketohexokinase (KHK) Inhibitor with an Unusual Thietane Amine Functional Group. J Med Chem. 2026 Jan 8;69(1):501-516. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
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상품명:
CAS No.:
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GS-1291269

All Ketohexokinase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

GS-1291269 Related Classifications

HY-180921 Related Classifications