Ivacaftor-d9
Based on 1 publication(s) in Google Scholar
Ivacaftor-d9 is a potent CFTR modulator and exhibits an EC50 value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research.
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- Purity: 99.79%
- CAS No.: 1413431-07-8
- 화학식: C24H19D9N2O3
- 분자량:401.55
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Ivacaftor-d9
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Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1413431-07-8
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Unlabeled Cas 873054-44-5
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Appearance Solid
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분자량 401.55
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화학식 C24H19D9N2O3
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Color White to off-white
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SMILES
CC(C)(C1=CC(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=C(C=C1NC(C2=CNC(C=CC=C3)=C3C2=O)=O)O)C
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Synonyms
VX-770-d9
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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bioRxiv
2026 Jun 8:2026.06.01.729306. PMID: 42282787
용액&용해도
DMSO : 50 mg/mL (124.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (274 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4903 mL | 12.4517 mL | 24.9035 mL | 62.2587 mL |
| 5 mM | 0.4981 mL | 2.4903 mL | 4.9807 mL | 12.4517 mL | |
| 10 mM | 0.2490 mL | 1.2452 mL | 2.4903 mL | 6.2259 mL | |
| 15 mM | 0.1660 mL | 0.8301 mL | 1.6602 mL | 4.1506 mL | |
| 20 mM | 0.1245 mL | 0.6226 mL | 1.2452 mL | 3.1129 mL | |
| 25 mM | 0.0996 mL | 0.4981 mL | 0.9961 mL | 2.4903 mL | |
| 30 mM | 0.0830 mL | 0.4151 mL | 0.8301 mL | 2.0753 mL | |
| 40 mM | 0.0623 mL | 0.3113 mL | 0.6226 mL | 1.5565 mL | |
| 50 mM | 0.0498 mL | 0.2490 mL | 0.4981 mL | 1.2452 mL | |
| 60 mM | 0.0415 mL | 0.2075 mL | 0.4151 mL | 1.0376 mL | |
| 80 mM | 0.0311 mL | 0.1556 mL | 0.3113 mL | 0.7782 mL | |
| 100 mM | 0.0249 mL | 0.1245 mL | 0.2490 mL | 0.6226 mL |
Ivacaftor-d9 Related Classifications
HY-13017S Related Classifications
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