KDM4-IN-3
Based on 1 publication(s) in Google Scholar
KDM4-IN-3 (Compound 15) is a KDM4 inhibitor (IC50 = 871 nM) that exhibits improved potency in biochemical assays. KDM4-IN-3 is cell-permeable and kills prostate cancer cells at low micro molar concentrations. KDM4-IN-3 inhibits growth of prostate cancer cell lines and increases the H3K9me3 abundance. KDM4-IN-3 can be studied in research for prostate cancer.
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- Purity: 99.36%
- CAS No.: 1068515-53-6
- 화학식: C17H14N4O
- 분자량:290.32
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Epigenetics Compound Library
HY-L005
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Histone Modification Research Compound Library
HY-L024
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Anti-Cancer Compound Library
HY-L025
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Anti-Cancer Metabolism Compound Library
HY-L083
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Anti-Prostate Cancer Compound Library
HY-L124
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Heterocyclic Compound Library
HY-L138
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Bioactive Compound Library Max
HY-L181
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Epigenetics Compound Library Mini
HY-L005M
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Methylation Compound Library
HY-L203
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
Publications Citing Use of MedChemExpress (MCE) KDM4-IN-3
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Biological Activity
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KDM4 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | GI50 |
8 μM
Compound: 15
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Cytotoxicity against human DU-145 cells assessed as growth inhibition after 48 hrs by alamar blue assay
Cytotoxicity against human DU-145 cells assessed as growth inhibition after 48 hrs by alamar blue assay
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[PMID: 34555281] |
| DU-145 | GI50 |
8 μM
Compound: 24b
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Antiproliferative activity against human DU-145 cells measured by Alamarblue assay
Antiproliferative activity against human DU-145 cells measured by Alamarblue assay
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[PMID: 35838529] |
| LNCaP | GI50 |
8 μM
Compound: 15
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Cytotoxicity against human LnCaP cells assessed as growth inhibition after 48 hrs by alamar blue assay
Cytotoxicity against human LnCaP cells assessed as growth inhibition after 48 hrs by alamar blue assay
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[PMID: 34555281] |
| LNCaP | GI50 |
8 μM
Compound: 24b
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Antiproliferative activity against human LNCaP cells measured by Alamarblue assay
Antiproliferative activity against human LNCaP cells measured by Alamarblue assay
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[PMID: 35838529] |
| PC-3 | GI50 |
>50 μM
Compound: 15
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Cytotoxicity against human PC-3 cells assessed as growth inhibition after 48 hrs by alamar blue assay
Cytotoxicity against human PC-3 cells assessed as growth inhibition after 48 hrs by alamar blue assay
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[PMID: 34555281] |
| PrEC | GI50 |
26 μM
Compound: 24b
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Antiproliferative activity against human PrEC cells measured by Alamarblue assay
Antiproliferative activity against human PrEC cells measured by Alamarblue assay
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[PMID: 35838529] |
| Prostate cell | GI50 |
26 μM
Compound: 15
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Cytotoxicity against human prostate epithelial cells assessed as growth inhibition after 48 hrs by alamar blue assay
Cytotoxicity against human prostate epithelial cells assessed as growth inhibition after 48 hrs by alamar blue assay
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[PMID: 34555281] |
KDM4-IN-3 (Compound 15) (1 μM-1 mM) does not inhibit FDH coupling enzyme[1].
KDM4-IN-3 (0-150 μM) has a non-competitive inhibition mechanism with H3K9me3 peptide substrate[1].
KDM4-IN-3 (0-200 μM) is uncompetitive with respect to the α-KG cosubstrate[1].
KDM4-IN-3 (0-100 μM) inhibits the growth of all PCa cell lines tested, including DU145 cells, PC3 cells, and a non-disease control cell line (HuPrEC), with similar efficacies and values of GI50 in the range of 8-26 μM[1].
KDM4-IN-3 (25 μM, 48 h) causes a highly significant decrease is PSA expression and a significant increase in H3K9me3 abundance as well as the amounts of the H3K9me3 epigenetic mark in histone H3 relative to static non-epigenetic motifs within histone H4 in PCa cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1068515-53-6
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Appearance Solid
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분자량 290.32
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화학식 C17H14N4O
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Color White to off-white
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SMILES
OC1=C(C2=CC=CC=C2)C(C)=NN1C3=NC4=CC=CC=C4N3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Death Discov
ATP2B4 driven chromatin compaction exacerbates pancreatic cancer radiotherapy resistance. [Abstract]2026 May 25. PMID: 42185253
용액&용해도
DMSO : 116.67 mg/mL (401.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4445 mL | 17.2224 mL | 34.4447 mL | 86.1119 mL |
| 5 mM | 0.6889 mL | 3.4445 mL | 6.8889 mL | 17.2224 mL | |
| 10 mM | 0.3444 mL | 1.7222 mL | 3.4445 mL | 8.6112 mL | |
| 15 mM | 0.2296 mL | 1.1482 mL | 2.2963 mL | 5.7408 mL | |
| 20 mM | 0.1722 mL | 0.8611 mL | 1.7222 mL | 4.3056 mL | |
| 25 mM | 0.1378 mL | 0.6889 mL | 1.3778 mL | 3.4445 mL | |
| 30 mM | 0.1148 mL | 0.5741 mL | 1.1482 mL | 2.8704 mL | |
| 40 mM | 0.0861 mL | 0.4306 mL | 0.8611 mL | 2.1528 mL | |
| 50 mM | 0.0689 mL | 0.3444 mL | 0.6889 mL | 1.7222 mL | |
| 60 mM | 0.0574 mL | 0.2870 mL | 0.5741 mL | 1.4352 mL | |
| 80 mM | 0.0431 mL | 0.2153 mL | 0.4306 mL | 1.0764 mL | |
| 100 mM | 0.0344 mL | 0.1722 mL | 0.3444 mL | 0.8611 mL |
KDM4-IN-3 Related Classifications
HY-132896 Related Classifications
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