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Cat. No.: HY-105383

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L 373890

L 373890 is a selective pyridinone acetamide thrombin inhibitor with a K_i of 0.5 nM. L 373890 shows highly selectivity for thrombin over trypsin (K_i of 570 nM), serine proteases plasmin, tPA, activated protein C, plasma kallikrein and chymotrypsin. L 373890 can be used for thrombosis research.

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CAS No.: 187162-33-0
화학식: C₂₂H₃₀N₆O₄S
분자량:474.58

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

L 373890 Chemical Structure

CAS No.: 187162-33-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

In Vivo

Occlusion is prevented in L 373890 out of animals in the rat Ferric chloride (HY-Y0266) model of arterial thrombosis at an IV infusion rate of 10 μg/kg/min^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 187162-33-0
분자량 474.58
화학식 C₂₂H₃₀N₆O₄S
SMILES

O=S(NC1=CC=C(C)N(CC(NCC2CCN(C(N)=N)CC2)=O)C1=O)(CC3=CC=CC=C3)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Philip E.J. Sanderson, et al. L-373,890, An achiral, noncovalent, subnanomolar thrombin inhibitor. Bioorganic & Medicinal Chemistry Letters. Volume 7, Issue 12, 17 June 1997, Pages 1497-1500.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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