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Cat. No.: HY-175562

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LDH-IN-4

LDH-IN-4 is a LDHA and LDHB inhibitor, as well as a ligand for target protein for PROTACs. LDH-IN-4 can be used to synthesize proteolysis-targeting chimeras (PROTAC), such as MS6105 (HY-152261). LDH-IN-4 is applicable to pancreatic cancer-related research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₃₀H₃₁N₅O₄S₂
분자량:589.73

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

LDH-IN-4 Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

LDHA

LDHB

In Vitro

LDH-IN-4 acts as a target protein ligand for MS6105 (HY-152261), a lactate dehydrogenase (LDH) proteolysis-targeting chimera (PROTAC) that effectively degrades LDHA and LDHB in a time- and ubiquitin-proteasome system-dependent manner, with anticancer activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 589.73
화학식 C₃₀H₃₁N₅O₄S₂
SMILES

NCCCCC#CC1=CC=CC(C2=NN(C(CC3CC3)=C2CC4=CC=C(C=C4)S(N)(=O)=O)C5=NC(C(O)=O)=CS5)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Sun N, et al.. Discovery of the First Lactate Dehydrogenase Proteolysis Targeting Chimera Degrader for the Treatment of Pancreatic Cancer. Journal of medicinal chemistry. 2023 Jan 12;66(1):596-610. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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