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Cat. No.: HY-151194

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LSD1/2-IN-4

LSD1/2-IN-4, a PCPA derivative, is an inhibitor of lysine-specific demethylase 1 (LSD1) and lysine-specific demethylase 2 (LSD2). LSD1/2-IN-4 inhibits LSD1 and LSD2 with K_i values of 0.11 μM and 130 μM, respectively. LSD1/2-IN-4 can be used for the research of several cancers including T-cell acute lymphoblastic leukemia (TALL).

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CAS No.: 2821068-09-9
화학식: C₉H₈BrF₂N
분자량:248.07

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

LSD1/2-IN-4 Chemical Structure

CAS No.: 2821068-09-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

KDM1/LSD1

All Histone Demethylase Isoforms :

In Vitro

LSD1/2-IN-4 shows strong inhibitory activity against both LSD1 and LSD2 with K_i values of 0.11 μM and 130 μM, respectively and not inhibits peroxidase with an IC₅₀ >500 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2821068-09-9
분자량 248.07
화학식 C₉H₈BrF₂N
SMILES

N[C@@H]1C[C@H]1C2=CC(F)=C(Br)C(F)=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hideaki Niwa, et al. Structure−Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2. ACS Medicinal Chemistry Letters Article ASAP. DOI: 10.1021/acsmedchemlett.2c00294

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

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Concentration _(start) Concentration _(start)

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Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
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LSD1/2-IN-4

All Histone Demethylase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

LSD1/2-IN-4 Related Classifications

HY-151194 Related Classifications