Lys-PEG1-Dasa
Lys-PEG1-Dasa is a BCR-ABL PROTAC degrader with an DC50 of 0.98 nM in K562 cells. Lys-PEG1-Dasa exerts growth inhibitory with IC50 of 0.4569 nM in K562 cells. Lys-PEG1-Dasa can be used for chronic myeloid leukemia research.
(Pink: Bcr-Abl ligand (HY-10181); Blue: Ligands for E3 Ligase ligand (HY-N0469); Black: linker).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- 화학식: C33H47ClN10O5S
- 분자량:731.31
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
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Biological Activity
Lys-PEG1-Dasa (0-2.5 nM, 0-48 h) efficiently downregulates BCR-ABL and exerts potent antiproliferative activity in K562 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:K562 cells
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Concentration:0, 0.01, 0.1, 0.25, 0.5, 0.75, 1 and 2.5 nM
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Incubation Time:48 h
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Result:Exerted potent antiproliferative activity with IC50 = 0.4569 nM
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Cell Line:K562 cells
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Concentration:0, 0.5, 1, 2.5 and 5 nM
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Incubation Time:0, 12, 24, 36 and 48 h
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Result:Efficiently downregulated BCR-ABL protein expression with DC50 = 0.4790 nM, Dmax = 99.1% at 5 nM.
Chemical Information
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분자량 731.31
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화학식 C33H47ClN10O5S
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SMILES
CC1=CC=CC(Cl)=C1NC(C2=CN=C(NC3=CC(N4CCN(CCOC(CCOCCNC([C@H](CCCCN)N)=O)=O)CC4)=NC(C)=N3)S2)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Chen X, et al. Mighty mini-PROTACs: an emerging class of degraders. Eur J Med Chem. 2026 Jan 5;301:118202. [Content Brief]
[2]. Zhang J, et al. Single amino acid-based PROTACs trigger degradation of the oncogenic kinase BCR-ABL in chronic myeloid leukemia (CML). J Biol Chem. 2023 Aug;299(8):104994. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lys-PEG1-Dasa Related Classifications
HY-180963 Related Classifications
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