Methylophiopogonanone B
Based on 2 publication(s) in Google Scholar
Methylophiopogonanone B is a homoisoflavonoid compound. Methylophiopogonanone B can be isolated from O. japonicus root. Methylophiopogonanone B promotes Rho activation and Tubulin depolymerization. Methylophiopogonanone B significantly increases GTP-Rho, but not GTP-Rac or GTP-CDC42. Methylophiopogonanone B induces cell morphological change via melanocyte dendrite retraction and stress fiber formation. Methylophiopogonanone B exhibits strong antioxidant activity. Methylophiopogonanone B can be used in the research of cervical cancer.
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- Purity: 99.84%
- CAS No.: 74805-91-7
- 화학식: C19H20O5
- 분자량:328.36
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보관:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Methylophiopogonanone B
More
Biological Activity
Methylophiopogonanone B exhibits strong antioxidant activity[1].
Methylophiopogonanone B (1 μM; 6 h) induces dendrite retraction and actin cytoskeleton rearrangement in normal epidermal melanocytes[2].
Methylophiopogonanone B (1-10 μM; 6 h) induces dose-dependent stress fiber formation and microtubule disorganization in HeLa cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 74805-91-7
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Appearance Solid
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분자량 328.36
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화학식 C19H20O5
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Color White to off-white
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SMILES
O=C1[C@H](CC2=CC=C(OC)C=C2)COC3=C(C)C(O)=C(C)C(O)=C13
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Food Chem
Effects of sun drying combined with baking processes on the flavor quality of Chongqing Tuocha raw tea. [Abstract]2025 Dec 30:497:146992. PMID: 41285060 -
Food Chem
Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]2025 May 31:489:144992. PMID: 40466530
용액&용해도
DMSO : 100 mg/mL (304.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
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- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Wang Y, et al. Homoisoflavonoids and the Antioxidant Activity of Ophiopogon japonicus Root. Iran J Pharm Res. 2017 Winter;16(1):357-365. [Content Brief]
[2]. Ito Y, et al. A novel agent, methylophiopogonanone B, promotes Rho activation and tubulin depolymerization. Mol Cell Biochem. 2007;297(1-2):121-129. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0454 mL | 15.2272 mL | 30.4544 mL | 76.1360 mL |
| 5 mM | 0.6091 mL | 3.0454 mL | 6.0909 mL | 15.2272 mL | |
| 10 mM | 0.3045 mL | 1.5227 mL | 3.0454 mL | 7.6136 mL | |
| 15 mM | 0.2030 mL | 1.0151 mL | 2.0303 mL | 5.0757 mL | |
| 20 mM | 0.1523 mL | 0.7614 mL | 1.5227 mL | 3.8068 mL | |
| 25 mM | 0.1218 mL | 0.6091 mL | 1.2182 mL | 3.0454 mL | |
| 30 mM | 0.1015 mL | 0.5076 mL | 1.0151 mL | 2.5379 mL | |
| 40 mM | 0.0761 mL | 0.3807 mL | 0.7614 mL | 1.9034 mL | |
| 50 mM | 0.0609 mL | 0.3045 mL | 0.6091 mL | 1.5227 mL | |
| 60 mM | 0.0508 mL | 0.2538 mL | 0.5076 mL | 1.2689 mL | |
| 80 mM | 0.0381 mL | 0.1903 mL | 0.3807 mL | 0.9517 mL | |
| 100 mM | 0.0305 mL | 0.1523 mL | 0.3045 mL | 0.7614 mL |
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