MYC-RIBOTAC
Based on 1 publication(s) in Google Scholar
MYC-RIBOTAC is a nucleic acid-targeting degrader (ribonuclease-targeting chimera, RIBOTAC) that targets the MYC internal ribosome entry site (IRES). MYC-RIBOTAC contains a MYC mRNA binding component and a small molecule that recruits and locally activates RNAse L1. MYC-RIBOTAC reduces MYC mRNA and protein expression levels, induces cell apoptosis, and can be used for antitumor research. MYC-RIBOTAC consists of pre-miR-155 binder Anticancer agent 167 (HY-156839), RNA binder NCI-B16 (HY-156215), and Linker Amino-PEG4-alcohol (HY-W008005).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.17%
- 화학식: C55H58N10O11S
- 분자량:1067.17
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보관:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) MYC-RIBOTAC
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Biological Activity
MYC-RIBOTAC (0-10 μM; 48 hours) decreases the abundance of MYC mRNA and protein levels in HeLa cells in a dose-dependent and RNase L dependent manner[1].
MYC-RIBOTAC (0-10 μM; 48 hours) has antiproliferative and induce-apoptotic effects in HeLa cells and Namalwa cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells and Namalwa cells
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Concentration:0-10 μM
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Incubation Time:48 hours
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Result:Had antiproliferative and induce-apoptotic effects in in HeLa cells.
Induced cell cycle arrest and provoked apoptosis and reduced colony formation by about 50% in Namalwa cells.
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Cell Line:HeLa cells
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Concentration:0-10 μM
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Incubation Time:48 hours
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Result:Decreased the abundance of MYC mRNA in HeLa cells in a dose-dependent and RNase L dependent manner, up to around 50% at a 10 μM dose with a concomitant reduction in MYC protein levels.
Chemical Information
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Appearance Solid
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분자량 1067.17
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화학식 C55H58N10O11S
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Color Light yellow to yellow
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SMILES
O=C(NC1=CC(NC(NC2=CC=C(C3=NCCN3)C=C2)=O)=CC(C(NCCOCCOCCOCCOC4=C(O)C=C(/C=C5SC(NC6=CC=CC=C6)=C(C(OCC)=O)C\5=O)C=C4)=O)=C1)NC7=CC=C(C8=NCCN8)C=C7
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
용액&용해도
DMSO : 100 mg/mL (93.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9371 mL | 4.6853 mL | 9.3706 mL | 23.4264 mL |
| 5 mM | 0.1874 mL | 0.9371 mL | 1.8741 mL | 4.6853 mL | |
| 10 mM | 0.0937 mL | 0.4685 mL | 0.9371 mL | 2.3426 mL | |
| 15 mM | 0.0625 mL | 0.3124 mL | 0.6247 mL | 1.5618 mL | |
| 20 mM | 0.0469 mL | 0.2343 mL | 0.4685 mL | 1.1713 mL | |
| 25 mM | 0.0375 mL | 0.1874 mL | 0.3748 mL | 0.9371 mL | |
| 30 mM | 0.0312 mL | 0.1562 mL | 0.3124 mL | 0.7809 mL | |
| 40 mM | 0.0234 mL | 0.1171 mL | 0.2343 mL | 0.5857 mL | |
| 50 mM | 0.0187 mL | 0.0937 mL | 0.1874 mL | 0.4685 mL | |
| 60 mM | 0.0156 mL | 0.0781 mL | 0.1562 mL | 0.3904 mL | |
| 80 mM | 0.0117 mL | 0.0586 mL | 0.1171 mL | 0.2928 mL |
MYC-RIBOTAC Related Classifications
HY-153713 Related Classifications
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