country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-121492

Copy Link Print Information

NSC 45576

NSC 45576 is a selective inhibitor of XendoU endoribonuclease and an inhibitor of CREB-CRE interaction, with an IC₅₀ value of 29 μM against Xenopus laevis XendoU. NSC 45576 binds to the active sites of XendoU and PP11, and inhibits CREB-CRE interaction. NSC 45576 can be used in cancer-related research such as breast cancer and gastric cancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1414586-62-1
화학식: C₂₀H₁₄N₂O₄S
분자량:378.40

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

NSC 45576 Chemical Structure

CAS No.: 1414586-62-1

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

NSC 45576 (compound 3) potently inhibits the endoribonucleolytic activity of recombinant Xenopus laevis His-XendoU with an IC₅₀ of 29 μM, and fully blocks activity at 200 μM^[1].
NSC 45576 inhibits the endoribonucleolytic activity of recombinant human His-PP11 in a dose-dependent manner^[1].
NSC 45576 acts as a non-specific inhibitor of CREB-CRE interaction in a high-throughput screening assay^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1414586-62-1
분자량 378.40
화학식 C₂₀H₁₄N₂O₄S
SMILES

O=C1C=CC=2C=CC=CC2C1=NNC3=CC=CC4=CC(=CC=C43)S(=O)(=O)O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Ragno R, et al. Identification of small-molecule inhibitors of the XendoU endoribonucleases family. ChemMedChem. 2011 Oct 04;6(10):1797-805. [Content Brief]

[2]. Xiao X, et al. Targeting CREB for cancer therapy: friend or foe. Current cancer drug targets. 2010 Jun;10(4):384-91. [Content Brief]

[3]. Jiang M, et al. Small molecule nAS-E targeting cAMP response element binding protein (CREB) and CREB-binding protein interaction inhibits breast cancer bone metastasis. Journal of cellular and molecular medicine. 2019 Feb;23(2):1224-1234. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기