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Cat. No.: HY-153096

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OICR12694

(Synonyms: JNJ-65234637)

OICR12694 (JNJ-65234637) is an orally active inhibitor of B cell lymphoma 6 (BCL6).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2360625-97-2
화학식: C₂₉H₂₈ClF₃N₈O₄
분자량:645.03

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

OICR12694 Chemical Structure

CAS No.: 2360625-97-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

OICR12694 (JNJ-65234637) is an orally active inhibitor of B cell lymphoma 6 (BCL6)^[1].

IC₅₀ & Target

B cell lymphoma 6 (BCL6)^[1]

All Bcl-2 Family Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
KARPAS-422	IC₅₀	0.092 μM Compound: 58	Antiproliferative activity against human KARPAS-422 cell assessed as cell growth inhibition incubated for 6 days by ATPlite reagent based luminescence assay Antiproliferative activity against human KARPAS-422 cell assessed as cell growth inhibition incubated for 6 days by ATPlite reagent based luminescence assay	[PMID: 36793435]

Chemical Information

CAS No. 2360625-97-2
분자량 645.03
화학식 C₂₉H₂₈ClF₃N₈O₄
SMILES

O=C1C2=C(N=C3N1CCC3)N(CC(NC4=C(Cl)C(F)=NC(N5[C@H](CN(CC5)C)C)=C4)=O)C=C2C6=CC(C(N)=O)=C(C(F)=C6F)O
Synonyms

JNJ-65234637
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mamai A, et al. Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor. ACS Med Chem Lett. 2023 Jan 12;14(2):199-210. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

OICR12694

All Bcl-2 Family Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

OICR12694 Related Classifications

HY-153096 Related Classifications